Drugs.txt

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Author:
Anonymous
ID:
77270
Filename:
Drugs.txt
Updated:
2011-04-04 12:49:56
Tags:
cardiac drugs
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Description:
cardiac drugs
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  1. Alpha receptors
    Constriction of blood vessels
  2. Beta 1 receptors
    • ^ HR
    • ^ contractility
    • ^ conductivity
  3. Beta 2 receptors
    • Dilation of bronchi
    • Dilation of blood vessels
  4. Dopamine
    • Sympathomimetics (adrenergic)
    • ^ myocardial contractility
    • ^HR (more than Dobutamine)
    • Dopamine-*Vasoconstriction
  5. Dobutamine
    • Sympathomimetics (adrenergic)
    • ^ myocardial contractility
    • ^HR (Dopamine more than Dobutamine)
    • Dobutamine- *Vasodilation
  6. Hydralazine
    • Directly dilates arterial system
    • reduces afterload
  7. Digoxin
    • Cardiac Glycosides
    • ^ force and velocity of myocardial contraction
    • decreases SA node firing
    • ^ refractory period of AV node
    • Decreases Artial automaticity
    • ^ Ventricular automaticity
    • ^ GFR and UOP
  8. Nitroglycerin
    • Relaxes vascular smooth muscles
    • -dilates primarily venous system- decreases preload
    • -Dilates arteries at high doses- decreases afterload
    • Relieves Vasospasm
    • Redistributes blood flow in the heart- improving myocardial O2 consumption
  9. Nitroprusside
    • Relaxes vascular smooth muscles
    • -Dilates venous system- decreases preload
    • -Dilates arteries at high doses- decreases afterload
  10. Nesiritide (Natrecor)
    • Acts as BNP
    • Dilates arteries- decreases SVR
    • Dilates veins- Decreases PAOP
    • Decreased Aldosterone and Norepinepherine levels
    • Promotes fluid and sodium release by blocking R-A-A system
  11. Calcium Channel Blockers
    • Blocks calcium flow through cardiac and smooth muscle cells
    • Ex: nifedipine(Procardia), amlodipine (Norvasc), nicardipine (Cardene), diltiazem (Cardizem), Verapamil (Calan)
  12. Ace inhibitors
    • Vasodilation- block conversion of angiotension I-> Angiotension II (interfere with breakdown of bradykin- produces cough)
    • Diuresis- inhibiton of aldosterone (Decreases retention of sodium and water, ^ K retention)
    • Ex: Captopril (Capoten), enalapril (Vasotec), lisinopril(Zestril),
  13. Angiotension II Blockers
    • Cause Vasodilation by blocking angiotension II
    • Ex: losartan (Cozar), valsartan (Diovan)
  14. Alpha Blockers
    • Ex: doxazosin (Cardura)
    • prazosin(Minipress), terazosin(Hytrin), phentolamine (Regitine)
  15. Alpha and Beta Blockers
    • Nonselective blockers
    • Ex: Carvedilol (Coreg), labetalol (Normodyne)
  16. Phenylephrine(Neo-Synephrine)
    • Vasoconsictors
    • Stimulates alpha receptors
    • - vasoconstricts, ^BP but doesn't ^HR
    • -^Aortic root pressure and CAPP
  17. Norepinephrine (Levophed)
    • Vasoconstrictor
    • Stimulates Alpha and Beta receptors
    • -Causes vasoconstriction and ^BP w/ minimal ^HR
    • - ^Aortic root pressure and CAPP
  18. Epinephrine
    • Stimulates Alpha and Beta receptors
    • -Causes vasoconstriction and ^BP w/ minimal ^HR- ^Aortic root pressure and CAPP
    • ^HR and myocardial Conractility
    • -acts as histamine antagonist in anahlyaxis
  19. Vasopressin (Pitressin)
    • ADH
    • Reduces portal venous pressure through vasoconstriction
    • Increases water reabsorption in renal tubals
    • Causes constriction of coronary, splanchic, GI, pancreatic, skin, and muscular vascular beds

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