B-ALL with Recurrent Genetic Abnormalities

Card Set Information

Author:
elzotter
ID:
77285
Filename:
B-ALL with Recurrent Genetic Abnormalities
Updated:
2011-04-04 14:03:27
Tags:
cytogenetics molecular lymphoma
Folders:

Description:
cytogenetics, molecular, lymphoma
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  1. t(12;21)(p13;q22)
    • TEL-AML1
    • (ETV6-RUNX1)

    Children

    Good
  2. t(1;19)(q23;p13)
    • E2A-PBX1
    • (TCF3-PBX1)


    Children > adults


    • Improved with
    • intensive chemo
  3. t(v;11q23)
    MLL (multiple partners)


    Infants under 1yr

    Poor
  4. t(9;22)(q34;q11)
    BCR-ABL1*


    Adults > children

    Poor

    * Most childhood ALL involves BCR minor breakpoint region (p190 fusion protein). ~50% adult ALL produce p230 fusion protein present in CML, and remainder produce p190.
  5. t(5;14)(q31;q32) (B-ALL with eosinophilia)
    IGH@-IL3

    Children & adults


    Uncertain (few cases reported)
  6. Hyperdiploid B-ALL (51-65 Chromosomes)
    • • Good prognosis
    • • Common in children
    • • Associated with gains of particular chromosomes
    • (without major structural abnormalities):
    • - X, 4, 6, 10, 14, 17, 18 usually gained as trisomies
    • - 21 present as either trisomy or tetrasomy in almost all cases
  7. Hypodiploid B-ALL (<46 Chromosomes)
    • • Poor prognosis
    • • Show loss of ≥ 1 chromosome
    • • Ranges from 45 chromosomes to near haploid (23-29 chromosomes)
    • • Seen in both adults and children (near haploid appears limited to children )
    • • Diagnosis of near haploid or low hypodiploid may be missed by karyotyping because hypodiploid clone can undergo endoreduplicatio (resulting in a near diploid number of chromosomes)

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