Common Cytogenetic Findings in Mature B-Cell Neoplasms

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Author:
elzotter
ID:
77295
Filename:
Common Cytogenetic Findings in Mature B-Cell Neoplasms
Updated:
2011-04-04 14:45:11
Tags:
cytogenetics molecular lymphoma
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Description:
cytogenetics, molecular, lymphoma
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  1. Follicular
    t(14;18)(q32;q21) (IGH@-BCL2)
  2. MALT
    t(11;18)(q21;q21) (API2-MALT1): lung/gastric*

    t(14;18)(q32;q21) (IGH@-MALT1): ocular adnexa/salivary gland

    t(3;14)(p14;q32)(IGH@-FOXP1): thyroid, ocular adnexa, skin

    Trisomy 3

    *Gastric MALT refractory to H.pylori eradication therapy
  3. Splenic Marginal Zone
    del(7)(q22-32)
  4. Diffuse Large B-cell
    BCL2 rearrangements [i.e. t(14;18)]

    3q27 (BCL6) rearrangements
  5. Burkitt
    Translocations of 8q24 (MYC) to either 14q32 (IGH), 2q11 (IGK), 22q11 (IGL)
  6. Mantle Cell
    t(11;14)(q13;q32) (CCND1-IGH@)

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