Diabetes Drugs

Card Set Information

Author:
eschott
ID:
77352
Filename:
Diabetes Drugs
Updated:
2011-04-04 17:42:01
Tags:
Drug List
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Description:
Drug List
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  1. What kind of a drug is Lispro Insulin?
    Rapid Acting Insulin therapy with peak.
  2. What kind of a drug is Regular Insulin?
    Short acting insulin treatment with peak
  3. What kind of a drug is Isophane (NPH)?
    An intermediate acting insulin treatment with peak
  4. What kind of a drug is Insulin Glargine?
    Long acting insulin treatment with NO peak.
  5. What kind of a drug is Insulin Dentemir?
    Long acting insulin treatment with NO peak.
  6. What is the mechanical action of insulin release in the beta cells?
    • Increased glucose --> increased ATP syntheis
    • Inhibition of K channels --> depolarization of cell
    • Increase of Ca2+ --> insulin release
  7. What kind of drug is insulin zinc extended?
    Long acting insulin treatment with peak.
  8. What kind of drug is rimonabant?
    • Appitite suppresor for DM 2
    • CB1 receptor antagonist
  9. What's the mechanism of action of Sulfonylureas?
    Inhibit K channel in b-cells --> depolarization --> release of insulin.
  10. What kind of drug is Tolbutamide?
    First generation Sulfonyluera (less potent)
  11. What kind of a drug is glyburide?
    Second generation sulfonylurea (more potent)
  12. What kind of drug is glipizide?
    Second generation sulfonylurea (more potent)
  13. What kind of drug is repaglinide?
    Oral; non sulfonylurea with same MoA on K channel to stimulate insulin secretion
  14. What type of drug is acabose?
    Inhibition of sucrose breakdown in gut to prevent hyperglycemia following meals (GI discomfort)
  15. What kind of drug is Pioglitazone?
    • Increase insulin sensitivity via synthesis of glucose transporters in skeletal muscle and adipose tissue
    • Decrease risk of MI & CVA
  16. What's the action of GLP-1?
    Glucagon like peptide that stimulates insulin release from B-cells
  17. What kind of drug is Sitagliptin phosphate?
    orally active; inhibits degredation of GLP-1 resulting in stimulation of insulin release
  18. What kinf of drug is Metformin?
    • Inhibition of liver gluconeogenesis
    • Bypass insulin mechanism to produce similar results

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