Androgens/Estrogens

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Anonymous
ID:
77376
Filename:
Androgens/Estrogens
Updated:
2011-04-04 18:53:43
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Drugs List
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  1. What's the transport mechanism for androgens?
    • Androgen binding protein - 30%
    • Albumin bound - 60%
    • Free - 2%
    • Active = Free + Albumin bound
  2. What happens to testosterone in the tissues?
    • Acts at androgen receptors
    • Converted to DHT via 5a-reductase
    • Converted to estrogen via aromatase
  3. What's the problem in Hypogonadism and how's it corrected?
    • Lack of androgen production.
    • Tx with testosterone supplements
  4. What's testosterone enanthate?
    Testosterone ester used in hypogonadism.
  5. What's the most common cause of Congenital Adrenal Hyperplasia and how is it treated?
    • 21-Hydroxylase deficiency (increased ACTH, Progesterone metabolites, DHEA)
    • Tx: oral hydrocortisone, fludrocortisone
  6. What's the clinical presentation of Andropause and the treatment?
    • Gradual decrease of suerum testosterone concentration 30-70 y/o
    • Tx: Transoderm, androderm, androgel
  7. What are clinical uses for testosterone?
    Andropause, Catabolic wasting (AIDS), Anemia
  8. What kind of drug is Flutamide?
    • Androgen receptor antagonist
    • Reciprocal LH/testosterone increase
    • More toxic
  9. What kind of drug is Bicalutamide?
    • Androgen receptor antagonist
    • Reciprocal LH/testosterone increase
    • Least toxic
  10. What kind of drug is cyproterone Acetate?
    • Weak androgen antagonist
    • Hirsutism treatment in women
  11. What kind of drug is Finasteride?
    • Blocks type II 5a-reductase --> prevent conversion to DHT in prostate
    • Tx: BPH
  12. What kind of drug is Dutasteride?
    • Blocks type I and II 5a-reductase --> prevent conversion to DHT in prostate
    • Tx: BPH
  13. What are the difference between estriol, estrone, premarin?
    • Estriol, a weak estrogen
    • Estrone, a weak estrogen
    • Premarin, from pregnant mare urine
  14. What kind of drug is 17a ethinyl estradiol?
    orally active estrogen treatment
  15. What kind of drug is equilin?
    • Equine estrogen
    • Avoids first pass metabolism in liver due to SO4 (removed in lower intestine)
  16. What kind of drug is Ethinyl estradiol/norethindrone acetate? What effects does it have?
    • Estrogen & Progesterone combined Hormone-Replacement Therapy (HRT)
    • Decrease Colon CA & bone fracture
    • Increase MI, CVA, breast CA
  17. What kind of drug is Tamoxifen?
    • SERM
    • Partial estrogen agonist
    • Agonist = bone & endometrium
    • Antagonist = breast
  18. What kind of drug is Raloxifene?
    • SERM
    • Partial estrogen agonist
    • Agonist = bone & endometrium
    • Antagonist = breast
  19. What kind of drug is Letrozole?
    • Aromatase inhibitor to block local estrogen production
    • Tx: Breast CA
    • SE: Hot flashes

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