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Distribution of Iron
- 70% Hb
- 4% Myoglobin
- 1% enzymes
- 25% stored
Iron: Dietary Need
17mg / day so that 1.7mg absorbed
Ferric vs Ferrous Iron Absorption
Most iron in food is in ferric form. Needs to be reduced by gastric juice to ferrous form to be absorbed.
Gastric bypass & iron absorption
Less gastric juice so less absorption. Will need iron supplements.
How iron is absorbed
Absorbed in the intestinal wall, carried by protein apoferratin, then carried by transferrin in blood to bone marrow.
Apoferratin & Transferrin
- Apoferratin absorbs iron in intestinal wall.
- Transferrin takes iron to marrow.
large protein that can carry 4500 ferrous ions
Iron accumulates -> Sideroblasts -> Siderocytes