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What class of drugs is Amiodarone?
What is the mechanism of action for Amiodarone?
- 1) Prolongation of action potential
- 2) Non-competative Alpha and Beta sympathetic blocking effects
- 3) Calcium Channel blocking effects
List the indications for use of Amiodarone
- 1) Supression of VFib
- 2) Supression of VTach
- 3) Management of Ventricular ectopy (PVC's)
What are the contraindications against using Amiodarone?
- 1) 2nd & 3rd degree heart block
- 2) Medication induced ventricular dysrythmias
- 3) Hypotension
- 4) Braycardia
- 5) Torsades de pointes
- 6) Profound sinus bradycardia
List the possible adverse reactions in the use of Amiodarone
- 1) Hypotension
- 2) Bradycardia
- 3) PEA (Pulselessness Electrical Activity)
- 4) CHF (Congestive Heart failure)
- 5) Nausea & fever
- 6) Abnormal liver function tests
- 7) Thrombocytopenia Disorder of having too few platlets)
List any drug interactions with Amiodarone
Amiodarone is incompatable with Sodium Bicarb
List the dosages and Administration routes for Amiodarone
- 1) VFib/ Pulselessness VTach: Initial dose 300mg slow IV push over 1-2 min in 10 cc of normal saline (NS)
- 2) Ventricular Ectopy (PVC): initial dose 150 mg slow IV Push over 10 min. Repeat dose 150 mg slow IV Push over 10 min continue if needed to a total of 300 mg administared
- 3) IV Infusion: 150 mg in 100 ml normal saline (NS) yeilds 1.5 mg/ml to be run at 0.5 - 1.5 mg per minute
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