PC: 1) psychoses 2) depression 3) myasthenia gravis 4) COPD. (Due to a short half-life of the drug, seizure activity may recur.)
Dos: (seizures) 5 to 10 mg IV/IM Ped: 0.5 to 2 mg IV/IM.
(acute anxiety) 2 to 5 mg IV/IM. Ped: 0.5 to 2 mg IM
(premed for cardioversion) 5 to 15 mg IV Ped: 0.2 to 0.5 mg/kg IV
Des: 1) ultra–short-acting nonbarbiturate hypnotic 2) no analgesic effects 3) limited cardiovascular and respiratory effects.
Ind: Induce sedation for rapid sequence intubation.
PC: 1) marked hypotension 2) severe asthma 3) severe cardiovascular disease
Dos: 0.1 to 0.3 mg/kg IV over 15 to 30 sec. Ped: children > 10 years, same as for adults
(Romazicon) Benzodiazepine Antagonist
Des: used to reverse the sedative, recall, and psychomotor effects of diazepam, midazolam, and the other benzodiazepines.
Ind: respiratory depression secondary to the benzodiazepines.
CI: 1) hypersensitivity to flumazenil or benzodiazepines 2) patients who take medication for status epilepticus or seizures 3) seizure-prone patients during labor and delivery 4) tricyclic antidepressant overdose
PI: 1) hepatic impairment 2) elderly 3) pregnancy 4) nursing mothers 5) head injury 6) alcohol and drug dependency 7) physical dependence on benzodiazepines