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What are the 6 jobs of Immunoglobulins (B CAN MO)?
- 1) B-cell activation
- 2) Complement pathway (IgG and IgM bind to C1)
- 3) ADCC
- 4) Neutralization
- 5) Mast Cell degranulation
- 6) Opsonization
What antibody participates in B-cell Opsonization?
What is the heterodimer that helps establish the mIg-BCR on B-cells?
Ig-Beta and Ig-Alpha
What receptor is expressed on a cell that needs to go through opsonization and phagocytosis?
FcReceptor (detects the bottom of the Y of the Ab)
What 5 cells participate in ADCC?
- *Phagocytic cells*
- 1) Monocytes
- 2) Macrophages
- 3) Neutrophils
- 4) NK cells
- 5) Eiosinophils
For ADCC, what Ab signals NK cell attack?
What Ab particularly binds Helminths (parasites) and Mast cells?
Which is the most common IgG Ab: 1,2,3, or 4?
What fluid contains IgA Ab's?
Secretions (tears, saliva, etc.)
What does IgE bind to?
- Mast Cells and Basophils
What two Ab serve as part of the BCR on Naive B-cells?
IgM and IgD