Card Set Information
IBS PHPR524 Test6
What are the sx of IBS?
altered bowel habits
physical and emotional distress
What are the proposed mechanisms of IBS?
Alterations in GI motility
Response to intraluminal contents
Neuroimmune modulation of gut functions
Psychosocial stressors may exacerbate severity of IBS sx
What medications are commonly used to relieve IBS abdominal pain?
Myorelaxants - none effective in U.S.
Opioid agonists - not proven
Peppermint oil - not definitive
What medications are used for IBS gas, but don't work?
What antibiotics may be beneficial for IBS bloating?
What is the MOA of antibiotics in IBS bloating?
decreased bacterial overgrowth to decrease volume and production of gas production
What is the MOA of fiber in C-IBS?
improve stool consistency and decrease colonic transit time
What is the recommended dose of fiber for C-IBS?
What traditional tx for constipation have no use in C-IBS?
stool softeners (docusate)
emollients (mineral oil)
stimulants (bisacodyl, cascara, senna phenolphthalein, ricinoleic acid)
osmotic lasatives (glycerin, lactulose, Mg, sodium phosphate, sorbitol)
What traditional tx for constipation may have some benefit in C-IBS?
What is the MOA of lubipristone in C-IBS?
activation of CLC
chloride channels, increasing intestinal secretions to increase motility
What type of IBS is lubipristone approved for?
C-IBS in women > 18yo
What is the MOA of loperimide in D-IBS?
decrease intestinal transit (watch high doses - could cause constipation)
increase intestinal and ion absorption
increase anal tone at rest
no effect on pain
Wht is the MOA of alosetron (Lotronex) in D-IBS?
slows colonic transit time
increases fluid absorption
What type of IBS is alosetron approved for?
Women w/ severe D-IBS refractory to conventional tx