HRT

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Author:
giddyupp
ID:
78246
Filename:
HRT
Updated:
2011-04-08 00:56:51
Tags:
HRT PHPR524 Test6
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Description:
HRT
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  1. What are the sx of menopause?
    • Hot flashes
    • Genitourinary atrophy
    • Osteoporosis
    • Insomnia and fatigue
    • Irritability
    • Depression
    • Impaired memory
    • Crying spells
    • Decrease in sexual function
  2. What is the tx for hot flashes?
    • estrogen at the lowest dose that controls the sx
    • continue for 3-5yrs
  3. What is the tx for genitourinary atrophy?
    • Nonprescription agents (replens)
    • Intravaginal estrogen
    • Systemic estrogen
  4. What are the benefits of estrogen in HRT?
    • Relieves hot flashes
    • Relieves genitourinary atrophy
    • Reduces hip fractures
    • Reduces vertebral fractures
    • Lowers LDL, increases HDL
    • Relieves insomnia and fatigue
    • Relieves mood changes
    • Improves sexual function
  5. What are the risks of estrogen in HRT?
    • Increased risk of endometrial cancer
    • Increased risk of breast cancer
    • Increased risk of CV outcomes
    • Bloating
    • HA
    • Breast tenderness
    • Unpredictable bleeding
  6. What are the benefits of progestin in HRT?
    Decrease risk of estrogen-induced irregular bleeding, endometrial hyperplasia, and carcinoma
  7. What are the risks of progestin in HRT?
    • Bloating
    • Wt gain
    • Irritability
    • Depression
    • Unpredictable bleeding for first 8-12 months
  8. What type of HRT is most appropriate for women with a hysterectomy?
    Unopposed estrogen (conjugated estrogen only)
  9. What is the disadvantage to Estrogen plus cyclic progestin in HRT?
    Regular menses every month until tx is d/c
  10. What is the advantage of estrogen plus continuous progestin in HRT?
    Menses only lasts for first 8-12mo of tx
  11. What are the other tx options for hot flashes?
    • Gabapentin (most effective, but not most used)
    • Clonidine (most effective, but not most used)
    • Clonidine patch (most effective, but not most used)
    • Megestrol acetate
    • Venlafaxine (most used and help mood changes)
    • Fluoxetine (most used and help mood changes)
    • Paroxetine (most used and help mood changes)
    • Mirtazapine
    • Methyldopa
    • Vitamin E
    • Soy
    • Black cohosh

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