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What is the first signal for B-cell maturation?
In a lymph node, where do the T-cells reside and B-cells reside?
- T-cells: parafollicular level
- B-cells: lymphoid follicle (outside edge)
What is the second activation signal of B-cells?
- B-cell to T-cell binding
- * CD40 to CD40L (CD154) ligand on T-cell
- * TH cytokines
What is the difference b/t a short and long-lived plasma cells when it comes to Ig?
- Short lived: produces IgM
- Long Lived: migrates to Bone marrow and gut where it produces IgA and IgG
How does a plasma cell become a memory cell?
Pass through affinity maturation
What mediates affinity maturation?
CD40 L (CD154) from T-cells
What causes class switching of Ab's in B-cells?
Cytokines released from T-cells when it is recognized that there is poor CD40-CD40 (CD154) binding
What Ab's does a memory cell express?
- mIgG, mIgA, mIgE
- **Only naive (mature) B-cells express IgM and IgD
What is the predominate Ab after affinity maturation?