- •Code for proteins that inhibit trans-formation by variety of mechanisms
- •Transformation involves loss of function of tumor suppressor genes (TSGs)
- •Both alleles must be inactivated for an impact on cancer development
- •Some DNA tumor viruses code for proteins that inactivate TSGs
Tumor suppresor genes inhibit proliferation, promote apoptosis. Both copies of tumor suppressor gene have to be lost, vs. oncogenes.
Oncogenes = specific mutation to make it active
tumor suppressor = any mutation that makes it not functional