ImmunoLec9Sp11

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Author:
matthewgraff
ID:
78477
Filename:
ImmunoLec9Sp11
Updated:
2011-04-09 18:53:18
Tags:
Immunology
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Description:
Antibodies
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  1. What fragment is produced from pepsin cleavage of IgG
    F(ab')2
  2. What fragment is produced from papain cleavage of IgG
    2 Fab segments and an Fc fragment
  3. What are the 6 effector functions of Iggs
    • 1. B-lymphocyte activation
    • 2. Complement activation
    • 3. Neutralization
    • 4. Opsonization
    • 5. Antibody dependent cell-mediated cytotoxicity (ADCC)
    • 6. Mast cell degranulation
  4. mIg (BCR) is in complex with what?
    • a disulfide linked heterodimer called Ig-a/Ig-B
    • -this is the signaling portion of the BCR complex
  5. IgM
    1. % total serum
    2. Half-life
    3. Location
    4. Function
    • 1. 5-10%
    • 2. 5 days
    • 3. secretions, BCR on naive B-cells (monomer)
    • 4. pentamer, bacterial/viral neutralization, activate complement, secreted during primary response
  6. IgG
    1. % total serum
    2. Half-life
    3. Location
    4. Function
    • 1. 80%
    • 2. 25 days
    • 3. blood, ECF
    • 4. bacterial/viral neutralization, ADCC, cross placenta, opsinization, activate complement, memory response
  7. IgA
    1. % total serum
    2. Half-life
    3. Location
    4. Function
    • 1. 10-15%
    • 2. 6 days
    • 3. external secretions (dimeric)
    • 4. neutralizing antibody at mucosal surfaces, memory and late primary response
    • - highest daily secretion of any antibody
  8. IgE
    1. % total serum
    2. Half-life
    3. Location
    4. Function
    • 1. < 1%
    • 2. 2-3 days
    • 3. blood
    • 4. activate mast cells and basophils when crosslinked by antigen, parasite defense (ADCC), memory response
  9. IgD
    1. % total serum
    2. Half-life
    3. Location
    4. Function
    • 1. < 1%
    • 2. 3 days
    • 3. blood
    • 4. B cell activation, BCR in naive B cells

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