ImmunoLec10Sp11

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Author:
matthewgraff
ID:
78493
Filename:
ImmunoLec10Sp11
Updated:
2011-04-09 18:52:23
Tags:
Immunology
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Description:
MHC molecules and Antigen Presentation
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  1. What are the APC's
    Dendritic cells (langerhans, interstitial DC's), Monocytes/Macrophages, B-cells, Thymic epithelial cells
  2. MHC's
    1. synonym
    2. display what to what
    • 1. HLA (Human Leukocyte Antigen)
    • 2. peptide antigens to cytotoxic and helper T-cells
  3. Class 1 MHC
    1. chains?
    2. Expression
    3. Binds
    4. for
    5. alleles
    • 1. 1 variable alpha and 1 non-variable B2
    • 2. all nucleated cells
    • 3. endogenous peptides
    • 4. Cytotoxic T-cells, CD8 binding site
    • 5. A, B, C
  4. Class 2 MHC
    1. chains?
    2. Expression
    3. Binds
    4. For
    5. Alleles
    • 1. variable alpha and B
    • 2. APC's
    • 3. exogenous peptides
    • 4. T-helper cells, CD4 binding site
    • 5. DP, DQ, DR
  5. Cytosolic Pathway is used for which MHC
    MHC class 1
  6. Transporter used in cytosolic pathway to move peptides into RER
    TAP transporter
  7. Endocytic Pathway is used for which MHC
    MHC class 2
  8. Special molecules used in loading MHC class 2
    • Invariant chain (hold chains together in RER,
    • DM ( assist in loading peptide into MHC

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