Pharm E3, IV Serotonin

Card Set Information

Author:
HLW
ID:
78505
Filename:
Pharm E3, IV Serotonin
Updated:
2011-05-10 16:18:32
Tags:
Pharm
Folders:

Description:
Pharm E3, IV Serotonin
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user HLW on FreezingBlue Flashcards. What would you like to do?


  1. ______ -> ______ -> ______ -> Serotonin
    • Dietary Tryptophan
    • 5-Hydroxy Tryptophan
    • 5-Hydroxytryptamine
  2. Serotonin is present in:
    • Banana's
    • Pineapples
    • Plums
  3. Physiological Roles of Serotonin:
    • GIT- Regulates Motility
    • CNS- Neurotransmitter
    • (Temp, Sleep, Aggression, Sensory, Pain)
  4. Metabolism of Serotonin
    Oxidative Deamination by MOA
  5. Excretion of Serotonin
    Urine
  6. Rapid Inj of Serotonin=>
    • Decreased Arterial Press w/ Bradycardia
    • Short period of Pressor Effect
    • Prolong Fall in Systemic BP
  7. Serotonin Receptors:
    • 5-HT1 (Gi Coupled)
    • 5-HT2 (Gq Coupled)
    • 5-HT3 (Ligand Gated Ion Channel)
    • 5-HT4 (Gs Coupled)
    • ...5-HT7
  8. Serotonin Agonists in nature=
    Ergot Alkaloids (Ergovine)
  9. Ergot Alkaloid receptors:
    • Adrenergic
    • Serotonic:
  10. Therapeutic Uses of Serotonin Agonists in nature:
    • Control Postpartum Hemorrhage
    • Induce Uterine involution
  11. How does Serotonin increase GI motility*
    Increase ACh release from Vagus
  12. Drugs classified as Serotonin Agonists:
    • Cisapride
    • Metclopramide
  13. Therapeutic Uses of Cisapride (3):
    • GI stasis
    • Reflux Esophagitis
    • Constipation/Megacolon (cats)
  14. Adverse Fx of Cisapride (1):
    Diarrhea
  15. Therapeutic Uses of Metclopramide (3):
    • Vomiting
    • GI stasis
    • Reflux Esophagitis
  16. Adverse Fx of Metclopramide (2):
    • Behavior/Mood
    • Constipation
  17. Serotonin Antagonists
    • Cyproheptadine (Periactin)
    • Ketanserin
    • Methysergide
    • Chlorpromazine
    • Phenoxybenzamine
  18. Therapeutic Uses of Cyproheptatine
    • Appetite Stimulation
    • Feline Asthma
    • Pruritis in cats
    • Photic Head Shaking in horses
  19. Adverse Fx of Cyproheptadine
    • Sedation
    • Anti-cholinergic activity
    • Anorexia
    • Lethargy
    • Polyphagia
  20. Therapeutic Uses of Ketanserin
    • Ergovaline- Induced, severe vasoconstriction
    • Reduce Intraocular Pressure (glaucoma)
  21. Therapeutic Uses of Methysergide
    • Migraines
    • Carcinoid Syndrome (GIT cancer)

What would you like to do?

Home > Flashcards > Print Preview