Parm E3, V Hemostatic/Anticoagulants

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HLW
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78526
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Parm E3, V Hemostatic/Anticoagulants
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2011-05-10 16:18:20
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Parm E3, V Hemostatic/Anticoagulants
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  1. Basic Process of Hemostasis (4):
    • Vascular Phase
    • Platelet Phase
    • Coagulation Phase
    • Fibrinolysis Phase
  2. Topical Hemostatics include (8):
    • Thromboplastin
    • Thrombin
    • Fibrinogin
    • Fibrin Foam
    • GelFoam
    • Oxidized Cellulose
    • Microcrystalline Collagen
    • Epi
  3. Systemic Hemostatics include (2):
    • Desmopressin Acetate
    • Protamine Sulfate
  4. In Vitro Anticoagulants (4):
    • Sodium Oxalate
    • Sodium Citrate
    • Edetate disodium
    • Heparine Sodium
  5. Anticoagulants used for transfusions (2):
    • Acid Citrate Dextrose
    • Citrate-Phosphate-Dextrose-Adenine
  6. Systemic Anticoagulants(2):
    • Heparin
    • Vit K Antagonists
  7. Vit K antagonists include (4):
    • Bishydroxycoumarin (Dicumarol)
    • Warfarin Sodium / Parwarfin / Coumodin
  8. Fibrinolytic Agents(4):
    • Streptokinase
    • Tissue Plasminogen Activator
    • Fibrinolysin
    • Urokinase
  9. Anti-Platelet Drugs (4):
    • Aspirin
    • Ticlopidine
    • Clopidogrel (Plavix)
    • Dipyrimadole
  10. Thromboplastin converts ___ to ___
    Prothrombin to Thrombin
  11. Admin of Thromboplastin:
    • Spray
    • Sponge
  12. Thrombin Converts ___ to ___
    Fibrinogin to Fibrin
  13. Clinical Uses of Thrombin (6):
    • Bleeding from Parenchymatous Tiss
    • Cancellous Bone
    • Dental Sockets
    • Laryngeal/Nasal Sx
    • Reconstructive Sx
    • Adhesive Agent for Skin Grafts
  14. Various Forms of Thrombin:
    • Powder
    • Solution
    • Foam
    • Gelatin Sponge
  15. Admin of Thrombin:
    NEVER IV!!!
  16. Fibrinogen requires endogenous ____ to convert into Fibrin
    Thrombin
  17. Clinical Uses of Fibrinogen:
    • Bleeding form denuded MM
    • Skin Grafts
    • Massive Blood Loss/Acute Hypofibrinogenemia
  18. ____ must be presoaked in thrombin sol
    • Fibrin Foam
    • GelFoam (bovine thrombin)
  19. How do Fibrin Foams work?
    They trap blood oozing at surface
  20. Which product can absorb several times its weight in whole blood?
    • Absorbable Gelatin Sponges
    • (GelFoam)
  21. Which topical hemostatic is antigenic?
    GelFoam
  22. ____ is applied to bleeding area, liquifies in 3-5 days and is absorbed in 4-6 weeks
    GelFoam
  23. Used as a Sx gauze/Sponge
    Oxidized Cellulose (Surgicel, Oxycel, Hemo-Pak)
  24. Oxidized Cellulose is intended to be used as a tempory packing b/c it can interfere with:
    • Bone Regeneration
    • Epithelialization
    • Cyst Formation
  25. Which Topical Hemostatic has a greater affinity for wet surfaces and adheres firmly?
    Microcrystalline Collagen
  26. Clinical Uses of Microcrystalline Collagen (2):
    • Clotting Factor Deficiencies
    • Liver or Sleep Sx
  27. Topical Hemostatic that provides immediate vasoconstriction
    Epi
  28. Topical Hemostatic that acts as astringent
    Styptics
  29. Which Topical Hemostatic can cause sloughing of tissue and hemorrhages?
    Styptics
  30. Vit K aids in the production of which clotting factors?
    • II
    • VII
    • IX
    • X
  31. Vit K Produces
    • Protein C
    • Protein S
  32. Synthetic Analog of Vasopressin*
    Desmopressin
  33. Functions of Desmopressin:*
    • Releases Stored vWf from endothelium and MO
    • Controls Cap bleeding
  34. Why does Vit K lose it's efficacy?
    Because vWf has to be restored
  35. Anticoagulant that interferes with thrombin and fibrinogen:
    Protamine Sulfate
  36. What drug can be used to antagonise Heparine Induced Hemorrhagic Action
    Protamine Sulfate
  37. What drug has antithrombic and anticoagulatory properties?
    Heparin
  38. Heparine Binds to ____, which induces a conformational change, which in turn inhibits ___ and activates ____
    • ...binds to Antithrombin III Factor...
    • ...Inhibits Thrombin...
    • ...activates factor Xa...
  39. Heparine is metabolized by...
    • Liver
    • Reticulo Endothelial System
  40. Clinical Uses of Heparin (5):
    • Prevention of Venous Thrombosis
    • Prevention of Pulmonary Embolism
    • Tx of Thromboemboli
    • DIC in cats
    • HW Tx
  41. Anticoagulant Action of Vit K antagonists become evident after ___, and are present for ___
    • 12-24 hours
    • 2-5 days
  42. Where are Vit K Antagonists....
    stored:
    Metabolized:
    Liver (both)
  43. Clinical Uses of Vit K Antagonists:
    Prophylaxis/Tx of Venous Thrombosis
  44. Fibrinolytic Agents are used to enhance the conversion of ____ to active ____
    ...Inactive Plasminogen to active Fibrinolytic Enzyme Plasmin
  45. Duration of onset of streptokinase=
    30mins - 12 hours
  46. Which Fibrinolytic Agent selectively acts on fibrin clots?
    Tissue Plasminogen Activator
  47. Clinical Uses of Tissue plasminogen Activator
    Lysis of Aortic Thromboemboli
  48. What drug is administered IP as a lavage to prevent adhesions in dogs?
    Urokinase
  49. Clinical Uses of Streptokinase (8):
    Eczema
    Dermatitis
    Cellulitis
    Hematomas
    Trauma
    Sinusitis
    Cysts
    Fractures w/ Fistulous Tracts
  50. Clinical Use of Anti-platelet drugs (7):
    • Thrombi associated w/ feline Cardiomyopathy
    • Pulmonary Endocarditis in HW Dz
    • DIC
    • Pulmonary thromboembolism
    • Laminitis
    • Navicular Dz
  51. Aspirin irreversibly inhibits ___, which inhibits ___
    Cyclooxygenase enzyme, which inhibits Prostaglandins & Thromboxane A2
  52. What potent aggregating factor is inhibited by aspirin
    Thromboxane A2
  53. Ticlopidine is a ____ inhibitor
    P2Y12
  54. What drug is structurally related to Ticlopidine
    Clopidogrel (Clavex)
  55. Funciton of cAMP
    antiaggregating compound
  56. What drugs inhibit cAMP?
    • Ticlopidine
    • Dypyrimadole

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