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Basic Process of Hemostasis (4):
- Vascular Phase
- Platelet Phase
- Coagulation Phase
- Fibrinolysis Phase
Topical Hemostatics include (8):
- Fibrin Foam
- Oxidized Cellulose
- Microcrystalline Collagen
Systemic Hemostatics include (2):
- Desmopressin Acetate
- Protamine Sulfate
In Vitro Anticoagulants (4):
- Sodium Oxalate
- Sodium Citrate
- Edetate disodium
- Heparine Sodium
Anticoagulants used for transfusions (2):
- Acid Citrate Dextrose
Vit K antagonists include (4):
- Bishydroxycoumarin (Dicumarol)
- Warfarin Sodium / Parwarfin / Coumodin
- Tissue Plasminogen Activator
Anti-Platelet Drugs (4):
- Clopidogrel (Plavix)
Thromboplastin converts ___ to ___
Prothrombin to Thrombin
Thrombin Converts ___ to ___
Fibrinogin to Fibrin
Clinical Uses of Thrombin (6):
- Bleeding from Parenchymatous Tiss
- Cancellous Bone
- Dental Sockets
- Laryngeal/Nasal Sx
- Reconstructive Sx
- Adhesive Agent for Skin Grafts
Various Forms of Thrombin:
- Gelatin Sponge
Admin of Thrombin:
Fibrinogen requires endogenous ____ to convert into Fibrin
Clinical Uses of Fibrinogen:
- Bleeding form denuded MM
- Skin Grafts
- Massive Blood Loss/Acute Hypofibrinogenemia
____ must be presoaked in thrombin sol
- Fibrin Foam
- GelFoam (bovine thrombin)
How do Fibrin Foams work?
They trap blood oozing at surface
Which product can absorb several times its weight in whole blood?
- Absorbable Gelatin Sponges
Which topical hemostatic is antigenic?
____ is applied to bleeding area, liquifies in 3-5 days and is absorbed in 4-6 weeks
Used as a Sx gauze/Sponge
Oxidized Cellulose (Surgicel, Oxycel, Hemo-Pak)
Oxidized Cellulose is intended to be used as a tempory packing b/c it can interfere with:
- Bone Regeneration
- Cyst Formation
Which Topical Hemostatic has a greater affinity for wet surfaces and adheres firmly?
Clinical Uses of Microcrystalline Collagen (2):
- Clotting Factor Deficiencies
- Liver or Sleep Sx
Topical Hemostatic that provides immediate vasoconstriction
Topical Hemostatic that acts as astringent
Which Topical Hemostatic can cause sloughing of tissue and hemorrhages?
Vit K aids in the production of which clotting factors?
Synthetic Analog of Vasopressin*
Functions of Desmopressin:*
- Releases Stored vWf from endothelium and MO
- Controls Cap bleeding
Why does Vit K lose it's efficacy?
Because vWf has to be restored
Anticoagulant that interferes with thrombin and fibrinogen:
What drug can be used to antagonise Heparine Induced Hemorrhagic Action
What drug has antithrombic and anticoagulatory properties?
Heparine Binds to ____, which induces a conformational change, which in turn inhibits ___ and activates ____
- ...binds to Antithrombin III Factor...
- ...Inhibits Thrombin...
- ...activates factor Xa...
Heparine is metabolized by...
- Reticulo Endothelial System
Clinical Uses of Heparin (5):
- Prevention of Venous Thrombosis
- Prevention of Pulmonary Embolism
- Tx of Thromboemboli
- DIC in cats
- HW Tx
Anticoagulant Action of Vit K antagonists become evident after ___, and are present for ___
Where are Vit K Antagonists....
Clinical Uses of Vit K Antagonists:
Prophylaxis/Tx of Venous Thrombosis
Fibrinolytic Agents are used to enhance the conversion of ____ to active ____
...Inactive Plasminogen to active Fibrinolytic Enzyme Plasmin
Duration of onset of streptokinase=
30mins - 12 hours
Which Fibrinolytic Agent selectively acts on fibrin clots?
Tissue Plasminogen Activator
Clinical Uses of Tissue plasminogen Activator
Lysis of Aortic Thromboemboli
What drug is administered IP as a lavage to prevent adhesions in dogs?
Clinical Uses of Streptokinase (8):
Fractures w/ Fistulous Tracts
Clinical Use of Anti-platelet drugs (7):
- Thrombi associated w/ feline Cardiomyopathy
- Pulmonary Endocarditis in HW Dz
- Pulmonary thromboembolism
- Navicular Dz
Aspirin irreversibly inhibits ___, which inhibits ___
Cyclooxygenase enzyme, which inhibits Prostaglandins & Thromboxane A2
What potent aggregating factor is inhibited by aspirin
Ticlopidine is a ____ inhibitor
What drug is structurally related to Ticlopidine
Funciton of cAMP