ImmunoLec14-15Sp11

Card Set Information

Author:
matthewgraff
ID:
78537
Filename:
ImmunoLec14-15Sp11
Updated:
2011-04-10 00:26:54
Tags:
Immunology
Folders:

Description:
B Lymphocytes
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  1. 4 steps of B cell maturation in bone marrow
    • 1. Progenitor B cell, expression of CD19
    • 2. Precursor B cell, Ig heavy chain has rearranged and is expressed on surface with surrogate light chain
    • 3. Immature B cell, heavy and light chains rearranged, expression of mIgM, negative selection
    • 4. Mature B cell, expression of mIgM and mIgD, exported from bone marrow to peripheral lymphoid
  2. T cell independant B cell activation (TI)
    • -nonprotein antigens crosslink BCR's or BCR to CR2
    • - limited class switiching
    • - limited memory cell generation
  3. Tcell dependent Bcell activation (TD)
    • - proteins or protein bound something
    • - TCR binds to MHC on Bcell
    • - CD40 on Bcell binds CD40L on Tcell
    • - extensive class switching, affinity maturation and memory cell generation

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