Toxicology Exam 3

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Author:
Rx2013
ID:
78842
Filename:
Toxicology Exam 3
Updated:
2011-04-11 11:42:18
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Immune Toxicology
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Immune Toxicology
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  1. cells responsible for humoral immune response
    b cells
  2. cells responsible for cellular immune response
    t cells
  3. antigen presenting cells
    • dendritic cells
    • macrophages
  4. Actions of endorphins
    • increase cytokin production
    • increase NK activity
    • increase macrophage activity
    • decrease T cell activity
    • decrease or increase humoral activity
  5. Assesment of immune response to asses toxicity
    • organ weight
    • hematology
    • bone marrow function
    • serum characteristics
    • histopathology
    • cell morphology
  6. Assesment of innate immume response
    • phagocytosis (radioactive rbc or latex beads)
    • nk cells
    • crp - elisa
  7. Assesment of acquired response (humoral)
    • PFC assay
    • elisa
  8. Assesment of acquired response (cellular)
    • CTL
    • delayed hypersensitivity response
    • t cell proliferative response
  9. National toxicology regulatory approach
    • tier 1 = general toxicity
    • tier 2 =CTL DHR antibody (more specific)
    • exposure should be for a min of 28 days
    • suppression of antibody response present
    • NK assay
  10. direct effects of xenobiotics may be expressed through
    the immune system
  11. indirect effects of xenobiotics may be expressed through
    the liver
  12. Tobacco results in
    • 3-5 fold increase in alveolar macrophages
    • reduced phagocytosis
    • bactericidal activity decreased
    • decreased antibody synthesis, NK cells
    • increased leukocytes
  13. Recombinant proteins result in
    • neutralizing antibody => hypersensitivity
    • hepatitis b vaccine is an example
  14. Ultraviolet exposure can result in
    • reduced hypersensitivity
    • reduced resistance
    • induction of suppressor T cells
    • TH1 => TH2 switch
  15. Hypersensitivity
    • over response
    • allergy
    • anaphylaxis
  16. Autoimmune disorders
    lack of self recognition
  17. Type 1 hypersensitivity mediated by
    IgE
  18. Type 2 hypersensitivity mediated by
    IgG
  19. Type 3 hypersensitivity mediated by
    IgG
  20. Type 4 hypersensitivity mediated by
    • Th1
    • Th2
    • CTL
  21. Assesment of IgE mediated hypersensitivity
    • skin test
    • elisa
    • RAST
    • inhalation test
    • contact hypersensitivity test (patch for 3-7 days)
  22. Metal may result in
    • pulmonary hypersensitivity
    • contact hypersensitivity
  23. Drugs may result in these hypersensitivities
    • type 1-4
    • penicillin
  24. Pesticides may result in these hypersensitivities
    contact and immediate
  25. latex may result in these hypersensitivities
    irritant and contact dermatitis
  26. cosmetics may result in
    • contact dermatitis
    • dermatoconjunctivitis
  27. enzymes may result in
    • rhinitis
    • conjunctivitis
    • asthma
  28. formaldehyde may result in
    • asthma
    • contact dermatitis
  29. molecules involved in autoimmune disorders
    • Ig
    • T cell receptor
    • MHC
  30. Drugs associated with scleroderma
    • toluene, xylene
    • tryptophan
    • silicones
  31. drus associated with systemic lupus erythematosus
    • phenothiazines
    • penicillamine
    • propylthiouracil
    • quinidine
    • l-dopa
    • lithium
    • trichloroethylene
    • silicones

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