Biostats 3

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Author:
eschott
ID:
79024
Filename:
Biostats 3
Updated:
2011-04-12 00:16:36
Tags:
Global Health
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Description:
Global Health
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  1. What risk groups should be treated based on a > 5mm TST?
    • HIV +
    • close TB contacts
    • Suggestive CXR
    • immunocompromised individual
  2. What risk groups should be treated based on a > 10mm TST?
    • Recent US immigrants from TB areas (asia, africa, russia, E. europe, L. America)
    • IV drug user
    • Frequenters of population dense areas
    • Mycobacteriaology workers
    • Children < 4
    • Minors exposed to high-risk adults
  3. What risk groups should be treated based on a > 15mm TST?
    Those with no known factors for TB
  4. Who is a close TB contact?
    Recenr/prolonged exposere to known/suspected TB.
  5. What are factors for TB transmission?
    • Infectiousness of TB
    • Type of envirnonment exposed
    • Duration of exposure
    • Virulency of bacilli
  6. How should close TB contacts be handled?
    • evaluated for LTBI and TB disease
    • + TST/IGRA --> LTBI Tx
    • - TST/IGRA --> retest in 8-10 weeks
  7. When can you start TB treatment on close contacts with a negative TST/IGRA?
    • Less than 8-10 weeks have passed since exposure:
    • Children < 5
    • Living with HIV
    • Immunocompromised
  8. What is the progression of TB treatment?
    • Initial Phase - 8 wks = 4 drugs used
    • Continuation Phase - > 8 wks = drugs used
  9. What's the initial regimine for TB?
    Isoniazid, Rifampin, Pyrazinamide, Ethambutol
  10. What are benefits of QFT-G test over TST?
    • Only 1 pt visit
    • Results in 24 hrs
    • No booster phenomenon
    • Less likely incorrect reading
    • No BCG FP
  11. What are disadvantages of QFT-G testing?
    • Samples must be processed in 12 hrs
    • Errors in running/interpreting test
    • Limited data for minors, immunosuppresive, HIV, blood disorders
  12. What's the basis for the QFT-G test?
    • Blood samples mixed with Ag for 16-24 hrs
    • Blood cells recognized Ag and release IFN-g
    • Results based on amount of IFN-g released

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