Neuro #34 Basal nuclei clinical.txt

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Author:
kepling
ID:
79203
Filename:
Neuro #34 Basal nuclei clinical.txt
Updated:
2011-04-12 20:05:57
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Neuro Basal nuclei clinical
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Neuro #34 Basal nuclei clinical
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  1. What is Hypokinetic disorder?
    Patient wants to perform an action but can't
  2. What are two forms of Hypkinetic disorder?
    • 1) Akinesia: no movement
    • 2) Bradykinesia: movements are very slow
  3. What pathways are affected by Hypokinetic disorders?
    Both direct and indirect
  4. What is Hyperkinetic disorder?
    Patient performs action without wanting to perform the action
  5. What pathway is affected by hyperkinetic disorder?
    Indirect (can't inhibit)
  6. What are three forms of Hyperkinetic disorder?
    • 1) ballism: rapid, flinging movements
    • 2) Athetosis: slow movements of limbs
    • 3) Chorea: rapid, flailing movements of limbs (huntingtons disease)
  7. What are the "kinesia" signs of Parkinson's disease?
    Akinesia, bradykinesia, resting tremors
  8. What specifically happens with the Basal Nuclei that causes parkinson's?
    • Pars Compacta of Substantia Nigra not producing Dopamine
    • **movements cannot be activated or enhanced
  9. What is a "kinesia" sign of Huntingtons?
    Chorea
  10. What specifically happens with the Basal Nuclei that causes Huntington's?
    • Indirect pathway inhibited at level of striatopallidal axons.
    • Medium spiny neurons degenerate
  11. What is a sign of Tardive dyskinesia?
    Smacking of lips, chewing movements
  12. What specifically happens with the Basal Nuclei that causes Tardive dyskinesia?
    Hypersensitivity to Dopamine from Substantia Nigra
  13. What is a sign of hemiballismus?
    Ballism (rapid, flinging movements)
  14. What specifically happens with the Basal Nuclei that causes Hemiballismus?
    Subthalamic nucleus damage = indirect pathway inhibited = direct pathway always causing activity

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