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indications for PPIs?
- GI treatment/prevention from NSAIDs
- Zollinger-ellison syndrom
Precautions of PPIs
Gastric carcinoma, exclude condition before starting treatment
Pregnancy - use ranitiine if possible othewise omeprazole is safe
Adverse effects of PPIS
headache, nausea, vomiting, diarrhoea
Rash, itch, decreased absorption of vitamin B12 (over time)
Dose of omeprazole?
20mg once daily for 4-8 weeks - PUD & GORD
prevention of a GI ulcer - 20mg daily
Dose for Lansoprazole?
30mg once daily for 4-8 weeks -GORD,PUD
Dose of esomeprazole?
20mg once daily - PUD/GORD
Prevention - 20mg daily
Dose of Pantoprazole?
40mg once daily for 4-8 weeks
GORD - 40mg 4-8 weeks, then increase to 40mg bd for the next 4 weeks
Dose of rabeprazole?
20mg once daily for 4-8 weeks - GORD & PUD
Counselling for PPIs?
Swallow whole, do not crush or chew tablet
Review maintaince therapy regularly
Tell your doctor if you develop black stools or coffee ground coloured vomit
Association between PPIS and pneumonia?
What supplements may be required in long term use with PPIs?
Calcium and vitamin D - due to increased fracture risk
Indications for ranitidine?
- Peptic ulcer disease
Advderse effects of ranitidine?
usually very well tolerared
may get hypotension - rare.
Dose of ranitidine?
150mg twice daily for dyspepsia
300mg daily for PUD
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