clinical chem exam 1 clinical lect

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vking
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clinical chem exam 1 clinical lect
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2010-02-24 14:05:42
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clinical chem exam 1 clinical lect
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clinical lect
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  1. Purpose of clinical laboratories
    • a.
    • Provision of clinically useful info for
    • diagnosis, monitoring, and treatment of disease

    • b.
    • Provision of info in biochemicals as indicators
    • of health status
  2. 4 areas of info provided by the clinical lab
    a. screening

    b. diagnosis

    c. monitoring

    d. prognosis
  3. differentiate the purpose of the clinical lab from other lab departments
    provision of info in biochemicals as indicators of health status
  4. Biochemical markers
  5. any hormone, enzyme, antibody, or other substance
    • that is detected in the urine, blood, or other body fluids or tissues that may
    • serve as a sign of a disease or other abnormality.
  6. 3 types of analytes clinical chem. Department
    measures
    • a.
    • organic biochemicals-carbs, lipids, proteins,
    • nucleic acids

    • b.
    • inorganic chemicals- ions, metals, gases


    • i. indicate
    • homeostasis-dynamic balance body has at keeping metabolic processes at an even
    • keel

    • c.
    • exogenous chemicals- drugs, vitamins
  7. homeostasis
    equilibrium kept by the body given internal and external stimuli
  8. types of analytic analysis used in clinical lab
    • a.
    • spectroscopy

    • b.
    • luminescence

    • c.
    • electroanalytical methods

    chromatography
  9. precision
    • a.
    • measure of reproducibility in a measurement


    • i. same
    • result repeatedly when testing same specimen
  10. accuracy
    - measure of how close a measured value is to the real value
  11. sensitivity
    ability to detect small quantities
  12. specificity
    no cross reactivity or interference from other substances
  13. 3 types of variables that need to be controlled
    in chemistry testing
    • a.
    • preanalytical

    • b.
    • analytical

    • c.
    • postanalytical
  14. types of specimens routinely used
    • a.
    • blood


    • i. serum-
    • liquid portion of clotted blood


    • ii. plasma-
    • liquid portion of unclotted blood, still contains fibrinogen

    • b.
    • urine

    • c.
    • CSF

    • d.
    • Feces

    • e.
    • Fluids


    i. Amniotic


    ii. Synovial


    iii. Pericardial


    iv. Pleural
  15. diurnal variation
    peaks at different times of the day

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