SFOS 12

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Author:
zf2010
ID:
80011
Filename:
SFOS 12
Updated:
2011-04-16 15:57:06
Tags:
Heart Mechanics
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Description:
SFOS 12
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  1. Excitation-contraction Coupling
    Matching stimulation with mechanical work
  2. What is the fundamental contracting unit in the heart?
    Cardiac myocyte
  3. What is the function of intercalated disks?
    • Attach two cells in a fiber
    • Provide gap junctions
  4. Syncytium
    Electrically coupled cell group
  5. Describe the mechanism of Ca release from SR
    • Ica channels open during Phase 2 plateau
    • Influx of trigger Ca
    • Causes calcium release channels in SR to open
    • Ca induced Ca release
  6. What molecule effects the contractile state? How?
    • Catecholamines (isoproterenol or norepinephrine)
    • Increase available Ca levels
  7. Preload
    • Wall tension prior to contraction
    • Increases with increased EDV as per law of la place
    • Approx. by end diastolic pressure
  8. Frank-Starling relationship
    • Relationship between EDV and cardiac performance
    • Increased venous return --> increased cardiac output
  9. Afterload
    • Force against which the cardiac muscle is working in systole
    • High afterload degrades ventricular performance
    • Approx. by systolic pressure
  10. Variables of cardiac performance
    • Contractile state
    • Preload
    • Afterload
    • Heart rate

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