ID 2, Exam 2

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Author:
mwbora
ID:
8012
Filename:
ID 2, Exam 2
Updated:
2010-02-24 18:48:08
Tags:
Ansas
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Description:
Rifampin
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  1. Ansa Macrolides: Overview
    • natural or semi-synthetic
    • belong to ansamycin group of antibiotics
    • these possess an aromatic ring system spanned by an alaphatic chain/bridge
  2. History
    • Semisynthetic derivative of rifamycin B
    • first used clinically in 1968
    • Rifampin = USAN (United States Adopted Name)
    • Rifampicin = INN (International Non-proprietary Name)
  3. Source; Rifamycin B
    • Amycolatopsis mediterranei is the source of the rifamycin complex -- Rifamycin A-E
    • Rifampin is a semi-synthetic derivative of rifamycin B
    • Rifamycin B is preferentially produced by the organism upon addition of sodium diethylbarbiturate to the fermentation medium

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