TCAs

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Author:
jmartin9
ID:
80292
Filename:
TCAs
Updated:
2011-04-18 00:20:27
Tags:
TCAs
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Description:
TCAs
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  1. What are indications for TCAs?
    • Major depression
    • Nocturnal enuresis

    • Adjuvant in pain management
    • Migraine prophylaxis
    • urge incontinence
  2. Precautions from TCA's??
    • Prostatic hypertrophy
    • Hyperthyroidism
    • Epilepsy (lowers seizure threshold)

    Pregancy - safe, but reduce dose in last week of pregnany to minimise baby having withdrawal effects
  3. Contraindications for TCAs??
    Serotonin toxicity - do not use within two weeks of stopping a MAOI or within two days of stopping meclobemide
  4. Adverse effects of TCAs?
    • Sedation, dry mouth, constipation, weight gain, orthostatic hypotension, dizziness, tremor.
    • SIAHD
  5. Dosage of Amitriptyline?
    Depression - 25-75mg daily

    Pain/migraine prophylaxis: 10-25mg at night
  6. Dosage of dothiepin?
    25-75mg once daily for depression
  7. Counselling for TCAs?
    Side effects - dizziness, dry mouth, constipation.

    May get a flare in depression in the first few weeks. Monitor.

    Take at night to reduce daytime sedation

    you may feel dizzy on standing, get up slowly

    May increase the effects of alcohol.

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