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Standard antipsychotic drugs are also called
- Dopamine Receptor Antagonists
What is an example of a low potency neuroleptic and why is it used less frequently than high potency?
Low-potency neuroleptics such as chlorpromazine (Thorazine) are used less frequently than high-potency neuroleptic medications because of problems with orthostatic hypotension.
What are 2 high potency neuroleptics?
- haloperidol (Halidol)
- fluphenazine (Prolixin)
** high-potency drugs have less sedation and fewer anticholinergic effects, they cause more EPS than low-potency agents.
What is Neuroleptic Malignant Syndrome?
Severe muscle rigidity with confusion, agitation, increased temperature, pulse, and blood pressure suggest a serious condition—
Atypical Antipsychotic Drugs are aka
serotonin-dopamine antagonists (SDAs)
- Clozapine (SDA) is relatively free of motor side effects
- is indicated for severely ill schizophrenic individuals who have failed to respond to standard therapy.
- Clozapine is not used as a first-line treatment because it may suppress bone marrow
The Blocking of dopamine reduces
the positive symptoms of schitzophrenia
Positive Symptoms of Schitzophrenia
- ¡Hallucinations-distortion of perceptions
- ¡Delusions-distortion of thought content
- ¡Disorganized speech
- ¡Grossly disorganized or catatonic behaviors
Negative symptoms of Schitzophrenia
- ¡Apathy (suppression of emotions)
- ¡Alogia (inablility to speak)
- ¡Lack of motivation
- ¡Blunted /flat affect (failure to express feelings)
- ¡Loss of emotional warmth
- ¡Impaired social skills
(-) symptoms are treated with ?
(+) symptoms are treated with ?
- (-) a typical antipsychotics
- (+) Hospitalization, Atypical antipsychotics and typical antipsychotics, Reduced stimuli, Interactive therapy
What are the major side effects of Typical Antipsychotics?
Major Side Effects: dopamine blockage (EPS), noradrenergic (Alpha 1)blockage, cholinergic blockage
What are some atypical antipsychotic examples?
- ¡Clozapine (Clozaril)
- ¡Risperidone (Risperdal)
- ¡Olanzapine (Zyprexa)
- ¡Quetiapine (Seroquel)
- ¡Ziprasidone (Geodon)
- ¡Aripiprazole (Abilify)
What is the tx for NMS?
- ¡D/C antipsychotics
- ¡Dantrolene- antidote for hyperthermia
- ¡Dopaminergics -Bromocriptine, amantadine
Risperidol has a high risk of
- orthostatic hypotension
- weight gain, sedation
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