ARV Drug interactions

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  1. Antacids and PPI
    • Decreases effect of Atazanavir
    • H2 blocker: separate use by 10 hours
    • Antacids: separate use by 2 hours
  2. Empty stomach
    • Didanosine
    • Indinavir
  3. Take with food
    PIs except Indinavir
  4. Avoid high fat meal
    • Efavirenz
    • Amprenavir
  5. Take with fatty meals
    • Tenofovir
    • Nelfinavir
  6. No food effect
    NRTI
  7. Darunavir
    Increased AUC with food and ritonavir by 30%
  8. Etravirine
    Fasting decreased absorption by 50%
  9. Maraviroc
    AUC decreased 50% with food
  10. Raltegravir
    No effect by food
  11. Lipid lowering agents
    • Use pravastatin or rosuvastatin
    • Atorvastatin with low dose and careful monitoring
  12. Anti-TB
    Rifampin
  13. Midazolam, triazolam
    Use with caution and low dose
  14. SSRI
    • Fluoxetine can cause serotonin syndrome
    • Use citalopram or escitalopram
  15. Trazadone
    Use lowest dose and monitor CNS and CV effects
  16. Neurlopetics
    • Variable effects
    • Titrate to response
  17. Others
    • Ergot alkaloids
    • Antihistamines - astimazole
  18. Carbamazepine
    Monitor levels
  19. Lamotrigine
    Titrate to effect due to decrease levels
  20. Phenytoin
    • Dual interaction
    • Use alternative
  21. Valproic acid
    • Dual interaction
    • Monitor levels
  22. Oral contraceptive
    Ethinyl estradiol and norethindrone decrease AUC
  23. Methadone
    Increase levels to avoid withdrawal
  24. Erectile dysfunction agents
    Cut dose by 50% with PIs
  25. St. John's Wort
    Decreased Indinavir
  26. Fluticasone
    Combination with Ritonavir increases concentration of fluticasone
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80843
Card Set
ARV Drug interactions
Description
ARV Drug interactions
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