cell bio

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  1. Glycocalyx ..
    • 1. provide mechanical support
    • 2. barriers to particles
    • 3. binding site for regulatory factors
    • 4. mediate cell interactions
  2. epithelial cells
    cell lining spaces in the body
  3. connective tissues
    composed to nonliving extracellular materials
  4. proteins in the plasma membrane have...?
    sugars attach to it
  5. extracelluar matrix...
    organized network of materials located beyond the plasma membrane
  6. basement membrane...
    • thick region around the ECM
    • -surrounds muscle/fat
    • -underlies the basal surface of epithelial tissues
  7. basement membranes...
    • 1. separate different tissues
    • 2. provide mechanical support
    • 3. barrier to macromolecule and cellular movement
    • 4. substrate for cell migration
    • 5. generate signals that maintain cell survival
  8. collagens..
    have 27 different types
  9. collagens provides...
    • -high tensile strength (resistant to pulling forces)
    • -alpha helical trimers bundle together into fibrils
    • -type I, II, III, (fibrillar) form rigid cables
    • -type IV (nonfibrillar) can form an interconnected lattice
  10. Type I, II, III of collages are..
    • adjacent collagens are strengthened by covalent cross-links
    • ----hydroxylysine - lysine
  11. collagens binds...
    fibronectins and integrins (cell surface)
  12. collagens with type IV have..
    • composed of helical and non-helical segments (felxibility)
    • and globular domains at each end (lattice contact points)
  13. diseases that are caused by defects in the collagen genes
    • 1. Osteogenesis imperfecta: fragile bones
    • 2. Ehlers-Danlos syndrome: hyperflexible joints, highly extensible skin
  14. proteoglycans.
    • = protein core + glycosaminoglycan (GAG) plysaccharide complex
    • -hyaluronic acids links many proteoglycans to form extremely large molecules
    • -fill the scaffold created by collagens
  15. proteoglycans
    • -chondroitin sulfate & karetin sulfate
    • -high amt of negative charge binds cations and H2O
    • -hydrated gel resists compressive forces
  16. fibronectins
    • -modular domains for interactions
    • - bind collagens, proteoglycans, integrins at cell surface
  17. importance of fibronectins
    • -linking ECM components together
    • -cell attachment to matrix
    • -cell migration
  18. laminins are..
    -3 polypeptides linked by disulfide bonds

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cell bio
2011-04-24 03:52:03

chapter 7
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