Pharmacology Final

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Author:
Rx2013
ID:
81657
Filename:
Pharmacology Final
Updated:
2011-04-25 12:00:25
Tags:
Sex Hormones
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Description:
Sex Hormones
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  1. Testosterone is responsible for
    • secondary male sex characteristics
    • maturation of sperm
    • promotion of protein biosynthesis
    • inhibition of gonad regulation cycle (- feedback)
  2. Conjugated Estrogens (Premarin) indications
    • symptoms of menopause
    • prevention of post menopausal osteoporosis
    • androgen dependent prostate carcinoma
    • breast cancer (palliation only)
  3. Contraindications for Premarin
    • associated with increased risk for MI and stroke
    • VT and PE risk
    • HTN/vascular diseases
    • Diabetes
    • Hypercholesterolemia
    • Lupus
  4. Drugs that increase elimination of estrogen
    • warfarin
    • rifampin
    • barbiturates
    • carbamazepine
    • phenytoin
    • griseofulvin
    • st. john's wort
    • primidone
  5. Drugs that reduce elimination of estrogens by the liver
    • erythromycin
    • ketoconazole
    • itraconazole
    • ritonavir
  6. Estradiol indications
    • symptoms of menopause
    • prevention of bone fractures associated with osteoporosis
  7. Contraindications for estradiol
    • asthma
    • breast cancer
    • breast feeding
    • CV disease
  8. Drug interactions with estradiol
    • amoxicillin/ampicillin
    • protease inhibitors
  9. Methyltestosterone uses
    • testosterone hormone replacement
    • breast cancer
    • post partum breast pain
  10. Warnings with methyltestosterone
    • can cause hypercalcemia in breast cancer pt
    • prolonged use may result in hepatitis or hepatic neoplasms
    • jaundice
    • prostatic hypertrophy in geriatric pt.
  11. ADEs in women taking methyltestosterone
    • amenorrhea/irregularities
    • inhibition of gonadotropin release
    • virilization
  12. ADEs in men taking methyltestosterone
    • gynecomastia
    • excessive erections
    • oligospermia at high doses
    • hirsutism
    • male pattern baldness
    • acne
    • retention of salts and water
  13. Liver ADEs of methyltestosterone
    • cholestatic jaundice
    • alterations in liver function tests
    • suppression of clotting factors 2,5,7 & 10.
    • increased serum cholesterol
  14. Drug interactions with methyltestosterone
    • increases effects of anticoagulants
    • elevastes serum levels of oxyphenbutazone
    • decreases blood glucose and insulin requirements
  15. Tamoxifen Warnings
    can cause hypercalcemia in some breast cancer patients with bone matastases
  16. Tamoxifen drug interactions
    • increases anticoagulat effects
    • increased risk of thromboembolic event when used with cytotoxic agents
    • decreased efficacy when used in combo with antidepressants metabolized by cyp2d6

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