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Pharmacology Final
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Adrenocorticoid Production
hypothalamus => anterior pituitary => ACTH acts on Adrenal Cortex => Cortisol
Effects of glucocorticoids on metabolism
stimulaiton of gluconeogenesis
mobilization of amino acids from extra hepatic tissue
inhibition of glucose uptake in muscle and fat
stimulation of fat breakdown
Effects of glucocorticoids on inflammation and immune function
potent anti-inflammatory & immunosuppressant
Disease states associated with glucocorticoids
Cushing's disease
Addison's disease
Hyperadrenocorticism
cushing's disease
excessive endogenous cortisol production
administer glucocorticoids for therapeutic purposes
Hypoadrenocorticism
Addison's disease
result of infectious disease or autoimmune destruction of the adrenal cortex
Dexamethasone
synthetic glucocorticoids
anti-inflammatory/immunosuppressant
Signs of dexamethasone overdose
retinal toxicity
glaucoma
subcapsular cataract
GI bleed
pancreatitis
Hydrocortisone
most important human glucocorticoid
essential for life
regulates/supports CV, metabolic, immunologic and homeostatic functions
Indications for hydrocortisone
relief of inflammatory and pruritic manifestations of dermatoses
Mechanism of action for hydrocortisone
binds to the cytosolic glucocorticoid receptor
ADEs with hydrocortisone
inhibition of bone formation
suppression of calcium absorption
delayed wound healing
Prednisonlone
synthetic glucocorticoid
Prednisonlone indication
primary or secondary adrenocortical insufficiency
psoriatic arthritis
arthritis
Prednisonlone mechanism of action
inhibits leukocyte infiltration at the site of inflammation
interferes with mediators of inflammatory response
suppress humoral immune responses
ADEs with prednisolone
high blood glucose levels
fluid retention
cushing's syndrome
all glucocorticoids are contraindicated in
systemic fungal infections
Methylprednisolone indications
1' or 2' adrenocortical insufficiency
congenital adrenal hyperplasia
non suppurative thyroiditis
hypercalcemia associated with cancer
dermal conditions
Author
Rx2013
ID
81681
Card Set
Pharmacology Final
Description
Glucocorticoids Part 1
Updated
4/25/2011, 4:42:44 PM
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