24 repro drugs

4 main categories of reproductive hormones

gonadotropic hormones are secreted by:

gonadotropic hormones include

stimulates ovarian follicle dev’p & sperm production

works w/ FSH to induce secretion of estrogen & dev’p of corpus luteum

stimulates production of progesterone by the corpus luteum & milk secretion by mammary glands “lactogenic hormone”

male hormones that are secreted mainly in the interstitial tissue of the testes in the male and secondarily in the adrenal glands of both sexes

____ stimulate the development of male characteristics (masculinization), include testosterone and androsterone

removal of the testicles

an inadequets production of androgens in the male may be due to:

characteristics of eunuchoid include:

_____ may also result in impotence or deficient sperm production (oligospermia)

uses of androgens include:

enlarged breast tissue in males

SI of ____:

-edema
- acne
-alopecia
-gynecomastia
-hirsutism (unusual hair growth)
-deep voice
-stunted growth
-jaundice
-increase LDL
-decrease HDL
insulin resistance

a serious side effect of illegal synthetic testosterone use (anabolic steroids)

all androgen agents fall under what classification category for abuse.

to avoid secondary exposure to children with testosterone gel what must be done:

PE for _____:

-use according to directions
- report decreased ejaculatory volume and excessive sexual stimulation especially in geriatric patients
-female sexual effects expect hirutism
-stunted growth

erectile dysfunction meds:

how are PDE (phosphodiesterase)inhibitors given and why?

medications that require sexual arousal for success

the first PDE inhibitor approved to treat ED?

SE of ____:

-HA, flushing, dizziness, vision abnormalities
-hearing loss, tinnitus
-cardiovascular events (angina, syncope, tachycardia, hypotension)

CI of _____:

-if erection persist more than 4hrs, seek medical assistance ASAP

* may indicate tissue damage and permanent potency loss

-older adults and PT's with cardiovascular risk factors

IA with _______:

-grapefruit juice (potentiates hypotension effects)
-nitrates, antiarryhtmics, macrolides, antifungals, quinolones

female sex hormone produced mainly by the ovary and secondarily by the adrenal gland

responsible for the development of female secondary sexual characteristics including breast enlargement and for the mentrual cycle.

effects the secretion of the FSH adn LH from the anterior pituitary gland in a complex way.....inhibits lactation and ovulation

estrogen meds

estrogen in combination w/ _______ is used in mgmnt of severe menopausal symptoms that do not respond to estrogen alone

when ____ & ___ are combined the risk of endometrial cancer is substantially reduced

is associated w/ increased risk of endometrial carcinoma

should not be used to prevent diseases due to risk of stroke or blood clots

should not be used for cardiovascular disease prevention

_____ uses include:
-bcp
-hypogonadism due to oopherectomy
-postmenopausal prevention of osteoporosis if unable to take any other medication
-postcoital use after rape or incest
-inoperable prostate cancer

SE of ____ with high doses:

-increased risk of thromboembolic disorders, MI, Stroke
-HA, migraine, depression
-increased risk of gallbladder disease
-skin discoloration
- vaginal bleeding
-hypercalcemia

CI for ______:

-anyone w/ hx of many conditions such as htn, liver, sob, breast cancer, DVT vaginal bleeding, visual disturbance, pregnancy

_______ should never be used to treat threatened abortions or if there are any possibilites of pregnancy

estrogen is also cautioned in

IA with ______:

-rifampin & isoniazid estrogenic activity
-corticosteroids (potentiates)
-lab tests
-sunscreen with estradiol topical emulsion (increase absorption)

hormone secreted by the corpus luteum and adrenal glands

responsible for changes in uterine endometrium in 2nd half of menstrual cycle in preparation for implantation of fertilized ovum, dev’p of placenta after implantation & dev’p of mammary glands

synthetic drugs that exert progesterone-like activity are called

_____ is also used for anorexia, weight loss, cachexia, and associated with aids syndrome

Uses of ______ include:

-treats amenorrhea & abnormal uterine bleeding
-concentration
-postmenopausal
-adjunctive/palliative therapy for endometrial & breast CA (megace)
-treats paraphilia esp. for pedophilia

___ has been used IM weekly to monthly to manage paraphilia (sexual deviancy in males) espcially for pedophilia and sexual sadism

Extended cycle oral contraceptives differ from traditional products by decreasing or eliminating the

by what primary mechanism do progestin only contraceptives prevent pregnancy

An intrauterine device containing a synthetic progestin is available and releases small amounts of ______ daily, providing 5 years of continuous contraception protection.

During administration of oxytocin, constant maternal and _______ monitoring is required

where is the pituitary gland located

Anabolic steroids are classified as ______ by th eDEA due to drug abuse

what type of contraceptive agent is indicated for breast feeding women?

Postcoital contraceptive agents must be administered within ___ hrs of unprotected intercourse

Depo-Provera injections may be considered among the risk factors for development of _______

how much dosing is needed for PDE when treating impotence

side effects such as ______ should be reported when using androgen therapy

progestin levonorgestral may be prescribed as ______

____ is used to treat impotance, congenital and acquired hypogonadism

_____ induces labor causing the uterus to contract

_____ is used to treat severe preclampsia or eclampsia

_____ are used for cervical ripening, therapeutic abortion in second trimester, & uterine evacuations in special circumstances

used in management for preterm labor

____ are most appropriate & effective for relief of vasomotor symptoms as long as women weigh risk & benefits with their doc

used to treat amenorrhea, uterine bleeding, and as contraception

the main producers of estrogens

drug used to terminate an unwanted pregnancy

used to prevent and treat postpartum and postabortion hemorrhage

serious fetal side effect of estrogen

type of cancer resulting from prolonged high-dose estrogen use

contraceptives containing two sequences of progestin doses

preparation containing the same proportion of estrogen & progestin in each tablet