chemotherapy agents side effects

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Author:
pdnguyen
ID:
82074
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chemotherapy agents side effects
Updated:
2011-04-27 01:16:51
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chemotherapy agents side effects
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chemotherapy agents side effects
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  1. busulfan
    • myelosuppression
    • VOD
  2. ifosfamide
    neurotoxicity
  3. cyclophosphamide
    • nephrotoxicity
    • neurotoxicity
  4. ifosfamide
    more neurotoxic than cyclophosphamide
  5. Melphalan
    varied absorption: carefully adjust dose
  6. dacarbazine
    potent vesicant
  7. carboplatin
    myelosuppression manifested as thrombocytopenia
  8. vincristine
    neurotoxicity
  9. vinblastine
    myelosuppression
  10. vinca alkaloids
    hyperuricemia
  11. docetaxel
    • more potent
    • neutropenia
  12. paclitaxel
    neutropenia
  13. taxane
    • hypersensitivity
    • extensively protein bound --> widely distributed except brain and testes.
  14. anthracyclines
    cardiac toxicity
  15. doxorubicin
    extravasation --> tissue necrosis (potent vesicant)
  16. doxorubicin liposomes
    hand & foot syndrome
  17. bleomycin
    lung toxicity = interstitial pneumonitis
  18. topotecan
    myelosuppression
  19. 5-FU
    GIT toxicity
  20. Cytosine arabinoside
    severe myelosuppression
  21. gemcitabine
    myelosuppression
  22. 6-thioguanine and 6-mercaptopurine
    • bone marrow suppression
    • liver toxicity
  23. cladribine
    severe bone marrow suppression

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