Pharmacology

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Author:
Samilou
ID:
82281
Filename:
Pharmacology
Updated:
2011-04-27 13:42:27
Tags:
Coagulation Modifiers
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Description:
Chapter 28
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  1. General term for any process that stops bleeding.
    Hemostasis
  2. Substances that promote coagulation.
    • platelets
    • Willebrand factor
    • activated clotting factor
    • tissue thromboplastin
  3. Substances that inhibit coagulation.
    • prostacyclin
    • antithrombin III
    • protein C and S
  4. What is the result of the cascade?
    Large concentration of clotting substance fibrin
  5. What substance located in the walls of the blood vessel is released when an extrinsic injury occurs?
    Thromboplastin
  6. The extrinsic factor is initiated by activation of which two activating factors?
    VII and X
  7. The intrinsic factor is initiated when which two substances come in contact on the inside of the damaged blood vessel?
    collagen and factor XII
  8. Which activating factor begins the clotting process in both pathways?
    X
  9. Name the 4 step process in clotting development.
    • 1- X combines with other factors to form prothrombin activator.
    • 2- Prothrombin activator transforms fibrogen into long strands of fibrin
    • 3- Thrombin activates factor XIII
    • 4- Drawing together fibrin strand in dense network
  10. How long does clotting take once the blood vessels is damaged?
    3-6 minutes
  11. What is Fibrinolysis?
    • Reversal of the clotting factor.
    • Transformation of plasmonogen to plasmin which dissolves fibrin strands of clot.
  12. Drugs that prevent or delay coagulation of blood.
    Anticoagulants
  13. Drugs that prevent platelet plugs from forming.
    Antiplatelets
  14. Drugs that promote coagulation.
    Antifibrinolytics
  15. Drugs that dissolve a preformed clot.
    Thrombolytics

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