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General term for any process that stops bleeding.
Substances that promote coagulation.
- Willebrand factor
- activated clotting factor
- tissue thromboplastin
Substances that inhibit coagulation.
- antithrombin III
- protein C and S
What is the result of the cascade?
Large concentration of clotting substance fibrin
What substance located in the walls of the blood vessel is released when an extrinsic injury occurs?
The extrinsic factor is initiated by activation of which two activating factors?
VII and X
The intrinsic factor is initiated when which two substances come in contact on the inside of the damaged blood vessel?
collagen and factor XII
Which activating factor begins the clotting process in both pathways?
Name the 4 step process in clotting development.
- 1- X combines with other factors to form prothrombin activator.
- 2- Prothrombin activator transforms fibrogen into long strands of fibrin
- 3- Thrombin activates factor XIII
- 4- Drawing together fibrin strand in dense network
How long does clotting take once the blood vessels is damaged?
What is Fibrinolysis?
- Reversal of the clotting factor.
- Transformation of plasmonogen to plasmin which dissolves fibrin strands of clot.
Drugs that prevent or delay coagulation of blood.
Drugs that prevent platelet plugs from forming.
Drugs that promote coagulation.
Drugs that dissolve a preformed clot.
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