Toxicology final

Card Set Information

Author:
Rx2013
ID:
82347
Filename:
Toxicology final
Updated:
2011-04-27 21:26:04
Tags:
Developmental toxicology
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Description:
Developmental Toxicology
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  1. Developmental toxicology
    study of teratology or structural birth defects
  2. High incidence of cervical cancer in women exposed to
    diethylstilbestrol
  3. Teratogenic substances
    • thalidomide
    • diethylstilbestol
    • ethanol
    • tobacco smoke
    • cocaine
    • valproic acid
    • retinoids
  4. Human developmental toxicants
    • radiation
    • infections
    • maternal trauma
    • metabolic imbalance
  5. 4 things that are needed when determining developmental toxicology
    • critical periods of susceptibility
    • endopoints of toxicity
    • dose response patterns
    • threshold concept
  6. Endocrine disruptor
    exogenous agent that interferes with actions of naturla hormones
  7. 4 modes of action of developmenta toxins involving endocrine systems
    • by serving as steroidal ligands
    • by modifying steroid hormone metabolism
    • by changing hypothalamic/pituitary hormone release
    • by uncharacterized proximate modes of action
  8. sources of endocrine disruptors
    • air, water soil
    • soybeans, legumes, flax, yams, clover
    • plants
    • household products
    • pesticides
  9. % of birth defects due to RDS
    4%
  10. % of birth defects due to maternal complications
    5%
  11. % of birth defects due to SIDS
    10%
  12. % of birth defects due to Prematurity/LBW
    16%
  13. % of birth defects of unknown cause
    46%
  14. Teratogenic drugs
    • ace inhibitors
    • ARBs
    • isotretinoin
    • vitamin A
    • Lithium
    • Male hormones

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