Card Set Information
same species, different genes
What is the strongest immune response
Lymphocytes and Abs that react to alloantigens from transplants
Which are the 6 most important alleles to match for a successful transplant?
How many haplotypes does each individual have?
20 (e.g. A-B + C-D)
Recipient MHC molecules present peptides from graft to T-cells
Donor MHC molecules present as self to T-cell
What cells attack chronic grafts?
T helper cells
What cells attack acute grafts?
Is graft rejection, CMI or Humoral mediated?
Both CMI and humoral
what is a
hyperacute transplant rejection
Predisposed antibodies attach alloantigen on graft
Alloreactive antibodies caused by previous exposure via grafts, transfusion, etc...
How fast does a
What two tests are performed to avoid hyperacute transplant rejection?
How fast does an
acute transplant rejection
What is the active cell in hyperactive and acute rejection?
: PMN and platelets
: Tcells (Th and CTL)
How fast does
Months to years
What is the active cell in chronic rejection?
fibroblasts, GF, and cytokines
** irreversible as they lay down scar tissue
What happens to survival rate as HLA mismatch increases (HLA-A, HLA-B, HLA-DR for 6 total)?
** heart and liver can survive less matches with immunotherapy
What are the two steps in successful chronic rejection?
Smooth muscle proliferation