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What is the presentation of aspirin?
300mg chewable tablet
- 300mg soluble or water dispersible tablets
What is the pharmacology of aspirin?
- Antiplatelet aggregation agent
- Actions: reduces platelet aggregation
- inhibits synthesis of prostaglandins (anti-inflammatory)
How is aspirin metabolised?
Converted to salicylate in the gut mucosa and liver
Excreted mainly by the kidneys
What is the primary emergency indication for aspirin?
To minimiae platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombosis in acute coronary syndrome
What are the contraindications for aspirin?
- Actively bleeding peptic ulcers
- Bleeding disorders
- Suspected dissecting AA
- Chest pain associated psychostimulant overdose if BP >160
What are the precautions for giving aspirin?
- Peptic ulcers
- Pts on anticoagulants e.g. warfarin
How is aspirin administered?
What are the side effects of Aspirin?
- GI bleeding
- Increased bleeding time
- Hypersensitivity reactions
Special notes and times of Aspirin
Do not give to children or adolescents with acute febrile illness
Anitplatelet effects last for the life of the platelet 8-10 days
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