Cancer genetics - pathology

(oncogene) --> CML

(oncogene)--> Burkitt's lymphoma

(oncogene)--> Follicular and undiff'd lymphomas (inhibits apoptosis)

(oncogene)--> Breast, ovarian, gastric carcinomas

(oncogene)--> Colon carcinoma

(oncogene)--> lung tumor

(oncogene)--> Neuroblastoma

(oncogene)--> MEN IIa and IIb (III)

(oncogene)--> Gastrointestinal stromal tumor (GIST)

• (tumor suppressor gene)--> 13q
• Retinoblastoma, osteosarcoma

• (tumor suppressor gene)--> 17q
• Breast and ovarian cancer

• (tumor suppressor gene)--> 13q
• Breast cancer

• (tumor suppressor gene)--> 17p
• Most human cancers, Li-Fraumeni syndrome

• (tumor suppressor gene)--> 9p
• Melanoma
• (melaNoma is on Nine)

• (tumor suppressor gene)--> 5q
• Colorectal cancer
• assoc with FAP

• (tumor suppressor gene)--> 11p
• Wilms' tumor

• (tumor suppressor gene)--> 17q
• Neurofibromatosis type 1

• (tumor suppressor gene)--> 22q
• Neurofibromatosis type 2
• Type 2 = 22

• (tumor suppressor gene)--> 18q
• Pancreatic cancer
• DPC - Deleted in Pancreatic Cancer

• (tumor suppressor gene)--> 18q
• Colon cancer
• DCC - Deleted in Colon Cancer

Prostate-specific antigen. Used to screen for prostate carcinoma. Can also be elev in BPH and prostatitis

Prostate carcinoma

Carcinoembryonic antigen. Very nonspecific but produced by ~70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas

Normally made by fetus. Hepatocellular carcinomas. Nonseminomatous germ cell tumors of the testis (e.g. yolk sac tumor)

Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors

Ovarian, malignant epithelial tumors

Melanoma, neural tumors, astrocytomas

Metastases to bone, obstructive biliary disease, Paget's disease of bone

Neuroblastoma, lung and gastric cancer

• Tartrate-resistant acid phosphatase. Hairy cell leukemia - a B-cell neoplasm
• "TRAP the hairy animal"

Pancreatic adenocarcinoma