Cancer genetics - pathology

Card Set Information

Author:
stedge5md
ID:
82820
Filename:
Cancer genetics - pathology
Updated:
2011-04-30 16:28:38
Tags:
Cancer genetics pathology
Folders:

Description:
Cancer genetics - pathology
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user stedge5md on FreezingBlue Flashcards. What would you like to do?


  1. abl
    (oncogene) --> CML
  2. c-myc
    (oncogene)--> Burkitt's lymphoma
  3. bcl-2
    (oncogene)--> Follicular and undiff'd lymphomas (inhibits apoptosis)
  4. erb-B2
    (oncogene)--> Breast, ovarian, gastric carcinomas
  5. ras
    (oncogene)--> Colon carcinoma
  6. L-myc
    (oncogene)--> lung tumor
  7. N-myc
    (oncogene)--> Neuroblastoma
  8. ret
    (oncogene)--> MEN IIa and IIb (III)
  9. c-kit
    (oncogene)--> Gastrointestinal stromal tumor (GIST)
  10. Rb
    • (tumor suppressor gene)--> 13q
    • Retinoblastoma, osteosarcoma
  11. BRCA1
    • (tumor suppressor gene)--> 17q
    • Breast and ovarian cancer
  12. BRCA2
    • (tumor suppressor gene)--> 13q
    • Breast cancer
  13. p53
    • (tumor suppressor gene)--> 17p
    • Most human cancers, Li-Fraumeni syndrome
  14. p16
    • (tumor suppressor gene)--> 9p
    • Melanoma
    • (melaNoma is on Nine)
  15. APC
    • (tumor suppressor gene)--> 5q
    • Colorectal cancer
    • assoc with FAP
  16. WT1
    • (tumor suppressor gene)--> 11p
    • Wilms' tumor
  17. NF1
    • (tumor suppressor gene)--> 17q
    • Neurofibromatosis type 1
  18. NF2
    • (tumor suppressor gene)--> 22q
    • Neurofibromatosis type 2
    • Type 2 = 22
  19. DPC
    • (tumor suppressor gene)--> 18q
    • Pancreatic cancer
    • DPC - Deleted in Pancreatic Cancer
  20. DCC
    • (tumor suppressor gene)--> 18q
    • Colon cancer
    • DCC - Deleted in Colon Cancer
  21. PSA
    Prostate-specific antigen. Used to screen for prostate carcinoma. Can also be elev in BPH and prostatitis
  22. Prostatic acid phosphatase
    Prostate carcinoma
  23. CEA
    Carcinoembryonic antigen. Very nonspecific but produced by ~70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas
  24. AFP
    Normally made by fetus. Hepatocellular carcinomas. Nonseminomatous germ cell tumors of the testis (e.g. yolk sac tumor)
  25. B-hCG
    Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors
  26. CA-125
    Ovarian, malignant epithelial tumors
  27. S-100
    Melanoma, neural tumors, astrocytomas
  28. Alkaline phosphatase
    Metastases to bone, obstructive biliary disease, Paget's disease of bone
  29. Bombesin
    Neuroblastoma, lung and gastric cancer
  30. TRAP
    • Tartrate-resistant acid phosphatase. Hairy cell leukemia - a B-cell neoplasm
    • "TRAP the hairy animal"
  31. CA-19-9
    Pancreatic adenocarcinoma

What would you like to do?

Home > Flashcards > Print Preview