-
what is a joint disorder that is uric acid crystal induced
GOUT
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what is infectious arthritis most commonly caused by?
bacteria
-
what are the three types of arthritis?
- rheumatoid arthritis
- juvenile rheumatoid arthritis
- spondylaropathies
-
what are the less inflammatory artristis disorders?
- osteoarthritis
- neurogenic athropahty
-
what reduces structural damage to joints?
etanercept
-
what is a systemic disorder-genetic basis and involves immune-mediated inflammation?
spondylarthritis
-
who is 3 times more common to form spondylarthritis?
MEN
-
what is the term used to indicate arthritis affecting only a few joints?
pauciarticular
-
what is the MOST COMMON joint disorder?
osteoarthritis
-
t/f the TMJ is affected, often PAINLESS with crepitation of osteoarthritis
true
-
what is the pharmacologic management for osteoarthritis?
- NSAIDS
- glucosamine
- chrondroitin sulfate
-
what is a painless form of arthritis?
the clicking of the jaw opening and closing
-
the synovial fluid of inflamed joints contains elevated levels of __________
prostoglandins
-
t/f corticosteroids are regarded as DMARDs because of complications associated with long-term use of steroids
false! are NOT regarded
-
what does DMARD stand for?
disease-modifying anti-rheumatic drugs
-
what are the oral side effects of DMARD?
- mucosal ulcerations (mucositis)
- gingival hyperplasia
- lupus erythematosus
- steven-johnson syndrome
- recurrent herpetic lesions
-
what is the first metatarsophalangeal joint affected with acute attacks from gout?
big toe
-
what is the origin of acute infectious arthritis?
bacterial
-
what are the the treatment options for inflammatory arthropathies? 3
- DMARDs (disease modifying anti rheumatic drugs)
- NSAIDs/Cox Inhibitors
- Corticosteroids
-
t/f acute infectious arthritis is usually multiple joints
FALSE FALSE FALSE...single joint!
-
what is a chronic autoimmune disease producing damage to joint tissues from inflammatory chemicals
rheumatoid arthritis
-
what are the inflammatory chemicals of rheumatoid arthritis? 3
- cytokines
- metalloproteinases
- tumor necrosis factor-alpha
-
what gender does rheumatoid arthritis usually affect?
women more than men
-
sjoren syndrome is a extra-articular manifestation of what type of arthritis?
rheumatoid arthritis
-
what is the pain management for rheumatoid arthritis?
DMARDs=disease modifying antirheumatic drugs (Etanercept)
-
what is a DMARDs to treat rheumatoid arthritis?
etanercept
-
t/f longstanidng RA is unassociated with oral hygiene
true
-
what does sjogren's syndrome cause with RA?
chronic dry mouth leading to associated conditions
-
what is the etiology of juvenile rheumatoid arthritis?
unknown; but possible genetic predisposition and immune mediated inflammation
-
what are the three forms of JRA?
- polyarticular
- pauciarticular
- systemic
-
what joints does pauciarticular JRA involve?
less than or equal to 4 joints
-
pauciarticular JRA is ___% prevalant, usually in young ____, and inflammation in the ___
-
what are the JRA pharmacologic management strategies? 4
DMARDs: antimalarial drugs, gold salts, minocylcine, monoclonal antibodies
-
what is a systemic disorder with genetic basis and involves immune mediated inflammation
spondylarthritis
-
what type of arthritis is 3 times more common in men
spondylarthritis
-
what are the characteristics of spondylarthritis?
- fever
- fatigue
- anorexia
- weight loss
- inflammation of axial skeleton
- large peripheral joints
- noturnal back pain
- back stiffness
-
what is the pharmacologic management of spondylarthritis
NSAIDS and DMARDs
-
what is any disease or condition affecting a joint
arthropathy
-
what is arthirits affecting only a few joints
pauciarticular
-
what are teh tissues surrounding a joint?
periarticular
-
what is arthritis affecting more than 4 joints
polyarticular
-
what is arthritis of the spine
spondyloarthropathy
-
what is the most common joint disorder
osteoarthritis
-
t/f with osteoarthritis the TMJ is affected and is often painful
false-painless
-
what is indicated for rapid relief of symptoms and control of systemic manifestations
corticosteroids
-
what prevents irreversible damage to joints and control of symptoms of pain ans swelling
DMARD and NSAIDs with or w/o corticosteriods
-
what are the oral side effects of DMARD?
mucosal ulceration (mucositis)
-
what are the tumor necrosis factor blocker agents?
adalimumab, etanercept, infliximab and abatacept
-
which tumor necrosis factor blocer agent is given by injection only?
adalimumab (Humira)
-
what drug is approved for ankylosing spondylitis, polyarticular JRA and RA
etanercept
-
what are the ADEs of etanercept?
- GI effects
- upper respiratory infection
- rare blood dyscrasias leading to increased infection and bleeding
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