pharm

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Author:
cassiedh
ID:
83029
Filename:
pharm
Updated:
2011-05-01 16:38:39
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ch24
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joint disorders
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  1. what is a joint disorder that is uric acid crystal induced
    GOUT
  2. what is infectious arthritis most commonly caused by?
    bacteria
  3. what are the three types of arthritis?
    • rheumatoid arthritis
    • juvenile rheumatoid arthritis
    • spondylaropathies
  4. what are the less inflammatory artristis disorders?
    • osteoarthritis
    • neurogenic athropahty
  5. what reduces structural damage to joints?
    etanercept
  6. what is a systemic disorder-genetic basis and involves immune-mediated inflammation?
    spondylarthritis
  7. who is 3 times more common to form spondylarthritis?
    MEN
  8. what is the term used to indicate arthritis affecting only a few joints?
    pauciarticular
  9. what is the MOST COMMON joint disorder?
    osteoarthritis
  10. t/f the TMJ is affected, often PAINLESS with crepitation of osteoarthritis
    true
  11. what is the pharmacologic management for osteoarthritis?
    • NSAIDS
    • glucosamine
    • chrondroitin sulfate
  12. what is a painless form of arthritis?
    the clicking of the jaw opening and closing
  13. the synovial fluid of inflamed joints contains elevated levels of __________
    prostoglandins
  14. t/f corticosteroids are regarded as DMARDs because of complications associated with long-term use of steroids
    false! are NOT regarded
  15. what does DMARD stand for?
    disease-modifying anti-rheumatic drugs
  16. what are the oral side effects of DMARD?
    • mucosal ulcerations (mucositis)
    • gingival hyperplasia
    • lupus erythematosus
    • steven-johnson syndrome
    • recurrent herpetic lesions
  17. what is the first metatarsophalangeal joint affected with acute attacks from gout?
    big toe
  18. what is the origin of acute infectious arthritis?
    bacterial
  19. what are the the treatment options for inflammatory arthropathies? 3
    • DMARDs (disease modifying anti rheumatic drugs)
    • NSAIDs/Cox Inhibitors
    • Corticosteroids
  20. t/f acute infectious arthritis is usually multiple joints
    FALSE FALSE FALSE...single joint!
  21. what is a chronic autoimmune disease producing damage to joint tissues from inflammatory chemicals
    rheumatoid arthritis
  22. what are the inflammatory chemicals of rheumatoid arthritis? 3
    • cytokines
    • metalloproteinases
    • tumor necrosis factor-alpha
  23. what gender does rheumatoid arthritis usually affect?
    women more than men
  24. sjoren syndrome is a extra-articular manifestation of what type of arthritis?
    rheumatoid arthritis
  25. what is the pain management for rheumatoid arthritis?
    DMARDs=disease modifying antirheumatic drugs (Etanercept)
  26. what is a DMARDs to treat rheumatoid arthritis?
    etanercept
  27. t/f longstanidng RA is unassociated with oral hygiene
    true
  28. what does sjogren's syndrome cause with RA?
    chronic dry mouth leading to associated conditions
  29. what is the etiology of juvenile rheumatoid arthritis?
    unknown; but possible genetic predisposition and immune mediated inflammation
  30. what are the three forms of JRA?
    • polyarticular
    • pauciarticular
    • systemic
  31. what joints does pauciarticular JRA involve?
    less than or equal to 4 joints
  32. pauciarticular JRA is ___% prevalant, usually in young ____, and inflammation in the ___
    • 40
    • girls
    • iris
  33. what are the JRA pharmacologic management strategies? 4
    DMARDs: antimalarial drugs, gold salts, minocylcine, monoclonal antibodies
  34. what is a systemic disorder with genetic basis and involves immune mediated inflammation
    spondylarthritis
  35. what type of arthritis is 3 times more common in men
    spondylarthritis
  36. what are the characteristics of spondylarthritis?
    • fever
    • fatigue
    • anorexia
    • weight loss
    • inflammation of axial skeleton
    • large peripheral joints
    • noturnal back pain
    • back stiffness
  37. what is the pharmacologic management of spondylarthritis
    NSAIDS and DMARDs
  38. what is any disease or condition affecting a joint
    arthropathy
  39. what is arthirits affecting only a few joints
    pauciarticular
  40. what are teh tissues surrounding a joint?
    periarticular
  41. what is arthritis affecting more than 4 joints
    polyarticular
  42. what is arthritis of the spine
    spondyloarthropathy
  43. what is the most common joint disorder
    osteoarthritis
  44. t/f with osteoarthritis the TMJ is affected and is often painful
    false-painless
  45. what is indicated for rapid relief of symptoms and control of systemic manifestations
    corticosteroids
  46. what prevents irreversible damage to joints and control of symptoms of pain ans swelling
    DMARD and NSAIDs with or w/o corticosteriods
  47. what are the oral side effects of DMARD?
    mucosal ulceration (mucositis)
  48. what are the tumor necrosis factor blocker agents?
    adalimumab, etanercept, infliximab and abatacept
  49. which tumor necrosis factor blocer agent is given by injection only?
    adalimumab (Humira)
  50. what drug is approved for ankylosing spondylitis, polyarticular JRA and RA
    etanercept
  51. what are the ADEs of etanercept?
    • GI effects
    • upper respiratory infection
    • rare blood dyscrasias leading to increased infection and bleeding

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