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cyclosporing, azathiprine and methotrexate...what are these
what are cyclosporines mainly used to prevent?
what is the ADE of cyclosporin?
when are cyclosprine, azathioprine and methotrexate used?
when NSAIDS fail
____ immunosuppressant is not to be used concurrently with NSAIDs
what immunosuppressants increase blood levelse causing toxicity?
cyclosporine and inhibitor sof CYP3A4
___ and ___ _____ agents can lead to cyclosporine toxicity
what is administered orally to prevent malaria?
t/f leflunomide has no dental drug interactions
t/f gold salts are restrict to RA
what immunosuppressant is used therapeutically in periodontal inflammation
what is used in cominations with methotrexate to reduce signs and symptoms of moderate to severe active RA
what are the ADEs of rituximab? 5
increased risk for infection
reactivation of viral diseases
severe mucocutaneous reactions
how is rituximab administred?
IV one time week for 4 weeks (one course
IV one time week up to 8 doses or eight weeks total (second course of 4 doeses)
last six months post infusion
what should you monitor for with a pt taking rituximab
development of blood dyscrasia
pulse rate and rhythm
recent history of angina
what type of appt should be used for a pt on immunosuppressants?
short appt and use mouth prop
what causes gout?
imbalance in purine metabolism, resulting in uric acid levels localizedin joint
what are the symptoms of gout
what is used most often for pharmacologic therapy for ACUTE gout
what inhibits cyclooxygenase and inhibits protsaglandin and thromboxane synthesis?
what is used for tx of ACUTE gout?
what is used for the management of CHRONIC gout in low doses to inhibit occurrence of acute attacks?
what drug inhibits steps in inflammatory process and is used for limited tx for ACUTE polyarticular gout?
if there is an ACUTE attack in a SINGLE joint what tx is done?
methylprednisolone injected directly
what are the agents that decrease uric acid synthesis of CHRONIC GOUT
allopurinal and oxypurinal
which chronic gout drug is generally well tolerated
t/f chronic gout tx with allopuinol may progress to stevens-johns syndrome
allopurinal should be discontinued when?
if rash develops
what is allopurinal used to tx
what does allopurinal do?
inhibits synthesis of uric acid
what should not be prescirbed with allopurinal use?
amoxicilin and ampicillin
what agents are used to decrease uric acid excretion?
joint disorders starting at immunosuppressants