CV disease

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Anonymous
ID:
83170
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CV disease
Updated:
2011-05-02 03:10:06
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CV disease
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CV disease
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  1. Risk factors for Heart Disease
    • High BP
    • Smoking
    • Dyslipidemia
    • Diabetes
    • Family history
  2. Management of HTN
    • 1. Lifestyle changes
    • 2. Diuretics, Beta blockers
    • 3. Angiotensin
    • 4. Ca2+ channel blocker
  3. 3 classes of diuretics
    • Thiazide
    • Loop
    • Potassium Sparing
  4. Side effects of Diuretics
    • Dizziness
    • Muscle cramps
    • N/V
    • Preg Cat B
    • CI: renal dysfunction
  5. Thiazide Diuretics (3)
    • Hydrochlorothiazide - Microzide
    • Polythiazide - Renese
    • Indapamide - Lozol
  6. Thiazide Diuretics MOA
    • Inhibition of Na/Cl tubules in kidney, causing increases urinary excretion.
    • Lower cariac output and lower BP
  7. Thiazide Diuretics Counseling points
    • Take in AM
    • Can take days to work
  8. Loop Diuretics
    • Furosemide - Lasix
    • Bumetanide - Bumex
    • Toresmide - Demadex
  9. Loop Diuretic MOA
    • Inhibit reabsorption of Na/Cl in ascending loop
    • INcreased urine output lowers cardiac output lowers BP
  10. Loop Diuretics Counseling Points
    • Don't take at bedtime
    • May need additional potassium in diet (hypokalemia)
  11. Potassium Sparing Diuretic (2)
    • Triamterene - Dyrenium
    • Amiloride - Midamor
  12. K-sparing diuretic MOA
    • Competitively inhibit aldosterone binding. Increases Na/Cl/H2O excretion.
    • Not K+/H+ excretion
  13. Beta Blockers (5)
    • Atenolol - Tenormin
    • Labetelol - Normodyne
    • Metroprolol Succinate - Toprol XL
    • Metroprolol Tartate - Lopressor
    • Propranolol - Inderal
  14. Beta blockers indications
    HTN, heart failure, MI, arrhythmias, angina
  15. Beta blocker MOA
    • competitively blocks B adrenergic receptors
    • decreases heart rate, BP and contractility
  16. Beta Blocker Counseling points
    • SE: Bradycardia
    • Effect can take 2 or more weeks
    • do not DC abruptly
    • Preg Cat C
  17. ACE inhibitors (5)
    • Lisinopril - Zestril
    • Ramipril - Altace
    • Captopril - Capoten
    • Benazepril - Lotensin
    • Enalapril - Vasotec
  18. ACE Inhibitor Indications
    • HTN
    • CHF
    • Acute MI
    • Prevention of MI
  19. ACE Inhib MOA
    • supress renin-angiotensin-aldosterone system (RAAS)
    • Inhibit ACE enzyme, prevents conversion of angiotensin 1 to angiotensin 2 to decrease vasoconstriction
  20. ACE inhib Counseling points
    • SE: dry cough or edema in face (rare emergency medical condition)
    • Preg Cat D
    • Can cause hyperalkemia
  21. Angiotensin 2 Receptor Blockers (ARBS)
    • Valsartan - Diovan
    • Losartan - Cozaar
    • Irbesartan - Avapro
    • Candesartan - Atacand
  22. ARBS MOA
    • inhibit RAAS by blocking binding of angiotensin 2
    • decrease vasoconstriction
  23. ARBS Counseling points
    • SE: HA, drowsiness
    • May take weeks to work
    • Preg Cat C
  24. Ca channel blockers (4)
    • Amlopidine - Norvasc
    • Nifedipidine - Procarida
    • Diltiazem - Cardizem
    • Verapamil - Calan
  25. Ca channel blockers MOA:
    • Blocks Ca channels
    • relaxation of coronary smooth muscle, vasodilation
    • decreased cardiac workload and lower BP
  26. Ca channel blockers counseling points
    • SE: Edema, constipation, flushing
    • Don't DC abruptly
    • No grapefruit juice (cyp3A4)
    • Preg Cat C

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