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Carbohydrate, hypertonic solution
Mechanism of Action
Rapidly increased serum glucose levels. Short term osmotic diuresis.
Hypoglycemia, altered level of consciousness, coma of unknown etiology seizure of unknown etiology, status epilepticus.
Extravasation leads to tissue necrosis. Warmth, pain, burning, thrombophlebitis, rhabdomyolysis, hyperglycemia.
Sodium bicarbonate, Coumadin.
25g/50-ml prefilled syringes (500 mg/ml).
Dosage and Administration
- Adult: 12.5-25 g slow IV; may be repeated as necessary.
- Pediatric: 0.5-1 g/kg/dose slow IV; may be repeated as necessary.
Duration of action
- Onset: less than 1 minute.
- Peak effect: variable
- Duration: variable
Administer thiamine prior to D50 in known alcoholic patients. Draw blood to determine glucose level before administering. Do not administer to patients with known CVA unless hypoglycemia documented.