Diuretics

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Snooze
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83619
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Diuretics
Updated:
2011-05-03 21:20:48
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diuretics
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Diuretics
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  1. What is the brand name, class of drug, and site of action of:

    Acetazolamide?
    • Diamox
    • Carbonic anhydrase inhibitor
    • Proximal tubule
  2. What is the brand name, class of drug, and site of action of:

    Methazolamide?
    • Neptane
    • Carbonic anhydrase inhibitor
    • Proximal tubule
  3. What is the usual dosing for Diamox and Neptane?
    Diamox: 250mg 1-4x/d

    Neptane: 50-100mg 2-3x/d
  4. What is the MOA of carbonic anhydrase inhibitors?
    Blocks NaHCO3 reabsorption by inhibiting carbonic anhydrase, which results in a renal loss of HCO3
  5. What is the brand name, class of drug, and site of action of:

    Mannitol?
    • Osmitrol
    • Osmotic diuretic
    • Thin descending limb, also at PT
  6. What is the MOA of osmotic diuretics like osmitrol and urea?
    Increases osmolarity of filtrate to hinder reabsorption of water
  7. Which class of diuretics may have an adverse effect of both hypoNa AND hyperNa, depending on the situation?
    Osmotic diuretics
  8. What are the 3 classes of diuretics that may cause an adverse effect of hyperuricemia?
    • Carbonic anhydrase inhibitors
    • Loop diuretics
    • Thiazide diuretics
  9. What are the brand names for:
    Bumetanide, Torsemide, Furosemide, and Etharcrynic Acid?
    • Bumex
    • Demadex
    • Lasix
    • Edecrin
  10. What is the MOA of loop diuretics?
    Inhibits Na/K/2Cl symporter in the thick ascending limb, which inhibits NaCl reabsorption
  11. Which two classes of diuretics increases excretion of uric acid with acute administration, but decreases it excretion w/chronic adminstration of the drug?
    Loop diuretics and thiazide diuretics
  12. What are the brand names for:
    Chlorthiazide, Chlorthalidone, HCTZ, Indapamide, Metolazone?
    • Diuril
    • Hygroton
    • HydroDiuril
    • Lozol
    • Zaroxolyn
  13. What is the MOA of thiazide diuretics?
    Inhibits NaCl reabsorption by blocking Na/Cl transporter in DCT
  14. What is the brand name, class of drug, and site of action of:

    Triamterene and Amiloride
    • Dyrenium and Midamor
    • K-sparing diuretics
    • Collecting tubule
  15. What is the MOA of K-sparing diuretics?
    Blocks ENaC to compete w/Na
  16. What is the brand name, class of drug, and site of action of:

    Spironolactone and Eplerenone?
    • Aldactone and Inspra
    • Aldosterone antagonists
    • Collecting tubule
  17. What is the MOA of aldosterone antagonists?
    Competitively inhibits binding of aldosterone to mineralcorticoid receptors (MR) which blocks Na reabsorption and K secretion
  18. Name four major adverse effects of aldosterone antagonists?
    • Gynecomastia
    • Impotence
    • Hirsutism
    • HyperK
  19. Which two classes of diuretics produces mild diuresis and should be used in combo w/another diuretic?
    K-sparing diuretics, aldosterone antagonists

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