Antineoplastic Agents Resistance

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Author:
pdnguyen
ID:
83637
Filename:
Antineoplastic Agents Resistance
Updated:
2011-05-03 22:14:02
Tags:
Antineoplastic Agents Resistance
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Description:
Antineoplastic Agents Resistance
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  1. nitrogen mustard
    • decreased drug influx
    • increased drug inactivation
  2. methotrexate
    decreased drug influx
  3. increased drug efflux
    increase P-glycoprotein
  4. cytosine arabinoside
    decreased drug activation
  5. 5-FU
    decreased drug activation
  6. increased drug inactivation
    glutathione S-transferase
  7. nitrosoureas
    increased drug inactivation
  8. dihydrofolate reductase
    increased concentration of target enzymes
  9. topoisomerase II
    increased concentration of target enzymes
  10. thymidylate synthase
    increased concentration of target enzymes
  11. hormone receptors
    decreased number of receptors
  12. vinca alkaloids
    mutations of tubulin
  13. kinase inhibitors
    mutations of tyrosine kinase
  14. alkylating agents: cisplatin
    • increased dna repair
    • formation of drug-trapping agents
  15. drug-trapping agents
    glutathione

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