therapy cancer test 2

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  1. Ovarian Cx Risk Factors
    • Few or no children
    • older age at marriage
    • older age at first birth
    • late menopaus
    • genetic syndromes (BRCA1/BRCA2, HPNCC/Lynch Syndrome)
  2. Things that decrease risk of Ovarian CX
    • lots of children
    • breast feeding
    • oral contraceptive use
    • Prophylactic oophorectomy in high risk patients
  3. Tumor Marker for Ovarian Cx
    CA-125
  4. Flowchart for who gets chemo for Ovarian Cx
    Image Upload
  5. Adjuvant Chemo for Ovarian Cx
    • Taxane: Paclitaxel vs Docetaxel
    • Platinum: Cisplatin vs Carboplatin
  6. SE Diff between Paclitaxel vs Docetaxel in Ovarian CX
    • Paclitaxel - more neuropathy
    • Docetaxel more severe neutropenia
  7. SE Diff between Cisplanin vs Carboplatin in Ovarian CX
    • Carbo - fewer SE in general, but more myelosuppression, esp thrombocytopenia
    • Cis- more neprhotoxicity and neuropathy
  8. How is ovarian chemo given
    interperotineally but still goes systemic
  9. Options for Adjuvant Ovarian Chemo
    Image Upload
  10. Which should you give first, paclitaxel or platinum?
    • Paclitaxel
    • Pay your taxes first
    • cisplatin decreases paclitaxel clearance
  11. Calvert equation
    • (target AUC)x(GFR+25)=total dose in mg
    • Used for carboplatin
    • Use Cockcroft and Gault OR Jellife equation for GFR
    • CAP GFR ESTIMATE AT 125ML/MIN
  12. Why use calvert formula with carbo
    • Decrease toxicity
    • Increase efficacy
  13. Tax/Plat Sensitive patients who relapse after 6 months
    Image Upload
  14. Treatment for Tax/Plat resistant Ovarian CX
    • topotecan(most likely)
    • liposomal doxorubicin (most likely)
    • Docetaxel
    • Gemcitabine
    • Paclitaxel weekly low dose
    • etoposide PO
Author:
krug0043
ID:
83656
Card Set:
therapy cancer test 2
Updated:
2011-05-04 03:55:03
Tags:
cancer
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Description:
cancer
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