Drug Induced Liver toxicity

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twinklemuse
ID:
83779
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Drug Induced Liver toxicity
Updated:
2011-05-05 02:20:25
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Drug Induced Liver toxicity
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Description:
Drug Induced Liver toxicity
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  1. >4 g of APAP
    intrinsic or idiosyncratic?
    intrin
  2. dose dependent
    intrinsic or idiosyncratic?
    intrin
  3. ellicited in all individuals
    intrinsic or idiosyncratic?
    intrin
  4. reproducible in all animal experiments.
    intrinsic or idiosyncratic?
    intrin
  5. distinctive histologic pattern for any given drug.
    intrinsic or idiosyncratic?
    intrin
  6. predictable appearance of lesions and usually a brief latent period.
    intrinsic or idiosyncratic?
    intrin
  7. no extrahepatic manifestations of hypersensitivity.
    intrinsic or idiosyncratic?
    intrin
  8. dose independent.
    intrinsic or idiosyncratic?
    idios
  9. phenytoin.
    intrinsic or idiosyncratic?
    idiosy
  10. small % of exposed individuals are affected.
    intrinsic or idiosyncratic?
    idiosy
  11. variable histologic pattern of lesions intrinsic or idiosyncratic?
    idios
  12. cannot be reproduced in animals.
    intrinsic or idiosyncratic?
    idios
  13. appearnce of lesions has no temporal relationship to the start of the drug therapy.
    intrinsic or idiosyncratic?
    idiosyn
  14. can have extrahepatic manifestation.
    intrinsic or idiosyncratic?
    idiosyn
  15. amiodarone morphology
    • phospholipidosis
  16. androgens morphology
    cannicular cholestasis
  17. aspirin morphology
    necrosis and steatosis
  18. oral contraceptives morphology
    • tumor
    • biliary problems
  19. fluoroquinolines morphology
    cholestasis
  20. lovastatin morphology
    cholestasis
  21. methotrexate morphology
    steatosis and necrosis
  22. phenytoin morphology
    allergic hepatitis
  23. valproic acid morphology
    steatosis
  24. vitamin A morphology
    cirrhosis
  25. Bactrim morphology
    cholestasis
  26. sulfonamide morphology
    necrosis
  27. isoniazid morphology
    necrosis
  28. carbamazepine morphology
    granulomas
  29. drugs that cause phospholipidosis
    amiodarone
  30. drugs that cause steatosis
    • amiodarone
    • aspirin
    • methotrexate
    • valproic acid
    • (fat VAAM)
  31. drugs that cause cholestasis
    • androgens
    • fluoroquinolines
    • lovastatin
    • bactrim
    • (Bile Frightens Liver Ache - Cholestasis)
  32. drugs that cause necrosis
    • aspirin
    • methotrexate
    • sulfonamides
    • isoniazid
    • (AIMS to kill)
  33. drugs associated with hypersensitivity (rash, liver tox)
    • ACEi
    • phenytoin
  34. This condition is NOT hepatocellular.
    A) necrosis
    B) cholestatic
    C) steatosis
    B) cholestatic
    (this multiple choice question has been scrambled)
  35. which has higher AST and ALT elevation?
    necrosis vs. steatosis
    necrosis
  36. alk phos is associated with...
    A) necrosis
    B) cholestatic
    C) steatosis
    B) cholestatic
    (this multiple choice question has been scrambled)
  37. ALT is elevated in...
    A) necrosis
    B) cholestatic
    C) steatosis
    A) necrosis
    (this multiple choice question has been scrambled)
  38. bilirubin is elevated in ...
    A) steatosis
    B) cholestatic
    C) necrosis
    B) cholestatic
    (this multiple choice question has been scrambled)
  39. 5-nucleotidase is elevated in..
    A) necrosis
    B) cholestatic
    C) steatosis
    B) cholestatic
    (this multiple choice question has been scrambled)
  40. AST is elevated in ...
    A) cholestatic
    B) necrosis
    C) steatosis
    B) necrosis
    (this multiple choice question has been scrambled)
  41. lactate dehydrogenase is elevated in...
    A) cholestasis
    B) necrosis
    C) steatosis
    B) necrosis
    (this multiple choice question has been scrambled)
  42. "antidote" therapy for methotrexate?
    • folic acid
    • leucovorin for rescue
  43. "antidote" therapy for immune mediated liver issue.
    steroids
  44. "antidote" therapy for APAP.
    N acetyl cysteine
  45. "antidote" therapy for steatosis.
    steroids
  46. "antidote" therapy for pruritis
    cholestyramine
  47. "antidote" therapy for valproic acid
    L carnitine
  48. "antidote" therapy for ascites
    • fluid
    • spironolactone
    • Lasix
  49. idiosyncratic reaction of
    isoniazid, trazodone, diclofenac, nefazodone, venlafaxine, lovastatin
    hepatocellular
  50. idiosyncratic reaction of chlorpromazine, estrogen, erythromycin
    cholestasis
  51. idiosyncratic reaction of halothane, phenytoin, sulfamethoxazole
    immunoallergic
  52. idiosyncratic reaction of diltiazen, sulfa drugs, quinidine
    granulomatous
  53. idiosyncratic reaction of didanosine, tetracycline, actylsalicylic acid, valproic acid
    microvesicular fat
  54. idiosyncratic reaction of amiodarone, tamoxifen
    steatohepatitis
  55. idiosyncratic reaction of nitrofurantoin, methyldopa, lovastatin, minocycline
    autoimmune
  56. idiosyncratic reaction of methotrexate, excess vitamin A
    fibrosis
  57. idiosyncratic reaction of nicotinic acid, cocaine, methylenedioxymethamphetamine
    vascular collapse
  58. idiosyncratic reaction of oral contraceptive, androgen
    oncogenesis
  59. idiosyncratic reaction of augmentin, carbamazepine, herbs, cyclosorine, methimazole, troglitazone
    mixed
  60. APAP increased dose effect
    • necrosis
    • apoptosis
  61. amiodarone cumulative dose effect
    steatohepatitis
  62. cocaine increased dose effect
    ischemic necrosis
  63. cyclosporine increased dose effect
    cholestatic injury
  64. methotrexate increased/cumulative dose effect
    • hepatocyte necrosis
    • fibrogenesis
  65. niacin increased dose effect
    ischemic necrosis
  66. OCP cumulative dose effect
    hepatic adenoma

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