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Parvo means __?__
small because it is the smallest virion
Parvovirus virion is __?__.
Parvo- genome is __?__.
linear ssDNA (
+ or -
) with self complementary hairpin structures at terminus that act as primers.
Parvo distinct characteristics include: __?__ (X6)
Stronge dependancy on cell cycle
Autonomous parvo replicates only in S-phase
Dependo- requires a helper virus
DNA must first become double stranded before trx
Site specific integration (adeno-associated virus)
Dependo- requires either __?__ or __?__ viruses to undergo replication.
-Adenovirus or Herpesvirus
Without AAV Dependo __?__ by __?__ because __?__.
establishes a latent infection by inserting its genome because Rep78 binds, cleaves and promotes integration.
Adenovirus provides __?__ which __?__.
transcriptional activator of AAV genes and cellular DNA replication genes
transports AAV mRNA to cytoplasm for Tln
Know replication process and Rep78 prot involvment.
1. Hair pin (ABCA' [3' end] with palandrom at other end
2. Host DNA pol extends 3' end (has -OH)
3. Rep nicks at A' of 3' end so hairpin can unfold and be copied on new stand
4. Hair pins reform (on old and new strands)
Examples of Parvovirus include: