Virology Papillomavirus

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Author:
p.reilly1227
ID:
83881
Filename:
Virology Papillomavirus
Updated:
2011-05-05 00:08:33
Tags:
Virology Papillomavirus
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Description:
Virology Papillomavirus
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  1. Papilla- means __?__.
    • nipple
    • referring to warts (pappiloma)
  2. Papilloma's virion is __?__
    naked icosahedral.
  3. Papilloma's genome is __?__
    circular dsDNA packaged as "minichromosomes"
  4. Papilloma's genes and proteins are expressed:
    • From two promoters and two poly A signals (early and late) from 1 DNA strand
    • Splicing
    • Early= E1-7 - stimulate cell proliferation and enable DNA rep
    • Late = L1-2 form capsid
  5. Papilloma examples include:
    HPV
  6. Papilloma's distinct characteristics include __?__. (3)
    • Replication pattern follows differentiation of epithelial cells in skin or mucosa
    • Early prot E6 and 7 regulate p53 and pRb (E2 downregulates E6 and 7 - regulatory sys)
  7. Papilloma and polyoma were in the same group "papova" (which means __?__) until it was discovered __?__ which seperated them into thier own families.
    • vacuolating
    • Polyoma needs both DNA strands to replicate

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