Card Set Information
Adenovirus's virion is __?__.
naked icosahedral with protruding knobbed fibers at vertices
Adenovirus's genome is __?__
linear dsDNA with short inverted terminal sequences and both 5' ends are covalently bound to a virus coded terminal prot.
1 promoter with different poly A signals (splicing)
Examples of Adenovirus include:
Ovine adenovirus D
Adenovirus distinct characteristics include: (3)
Multiple mRNA arise by extensice alternative splicing
1 strong promoter with multiple poly A signals ( each stop is a different prot)
primed by terminal prot
( uses own
__?__ is the role of E1A and is associated with which other virus?
activates trx and induces the host cell to enter S phase of cycle by binding pRb)
__?__ is the role of E1B.
Induces cell growth by promoting degredation of p53 and suppresses apoptosis
The role of E3 is to __?__.
block MHC transport to plasma membrane
Cell immune evasion
What is unique about Adenovirus replication?
dsDNA is primed by protein (not RNA)
replication creates single strand by seperating two strands.
Single strand is covered in "DNA binding prot" and cyclizes creating a "panhandle".
Another Pol can the replicate this strand giving two complete dsDNA copies