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doesn't respond to bronchidilation, switches to respiratory acidosis=>resp failure
Asthma most common chronic disease of childhood, can occur at any age
- Extrensic: Allergy (strongest), seasonal or perennial, chronic exposure to airway irritants (smoke pollutants cold heat weather changes, strong odors or perfumes).
- Intrinsic factors: resp inf, ex induced, meds- stress emo upset, fatigue, GERD, ace inhibitors
-What sends mast cells?
-Chemical mediators causing vasodilation, fluid leak, WBC accum, cap permeability and bronchoconstriction
-asthma tx aimed at...:
- -histamine, leukotreines, prostaglandins and other chem meds
- ...why anything other than bronchodilators not for emergency, can only prevent, not reverse
Why glucocorticoids so effective tx asthma
prevents so much of immune response. Even prevents IgE from getting involved.
-#1 recurr asthma attacks?
-sx of impending attack
- -miss scheduled meds.
- -inc need for albuterol, act. lims, frequent waking, variability in peak flow rate
Classic asthma sx
dyspnea, wheezing, (bronchospasms leading to) coughing
Prog asthma exacerbation sx include